MR of the hypothalamic-pituitary axis in Langerhans cell histiocytosis

M. Maghnie, M. Arico, A. Villa, E. Genovese, G. Beluffi, F. Severi

Research output: Contribution to journalArticle

Abstract

PURPOSE: To describe the MR findings in the hypothalamic pituitary area in children with Langerhans cell histiocytosis and to define those MR alterations especially associated with the risk of developing diabetes insipidus. METHODS: The hypothalamic-neurohypophyseal axis was studied by sagittal and coronal 1.5 T1-weighted MR imaging in 14 children with Langerhans cell histiocytosis (five with diabetes insipidus) and in 28 low- stature controls, ages 6-14 years. RESULTS: The pituitary stalk was thicker in seven/14 patients (three with diabetes insipidus) than in controls (P <.05). Bright posterior pituitary signal was undetectable in children with diabetes insipidus and in one/9 without diabetes insipidus. CONCLUSIONS: Thickening of the hypothalamus and/or the pituitary stalk in the absence of the posterior pituitary bright signal is seen in children with Langerhans cell histiocytosis with overt diabetes insipidus. Those Langerhans cell histiocytosis patients without diabetes insipidus but showing thickened stalk with or without posterior pituitary bright signal could be at high risk to develop diabetes insipidus.

Original languageEnglish
Pages (from-to)1365-1371
Number of pages7
JournalAmerican Journal of Neuroradiology
Volume13
Issue number5
Publication statusPublished - 1992

ASJC Scopus subject areas

  • Clinical Neurology
  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology

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    Maghnie, M., Arico, M., Villa, A., Genovese, E., Beluffi, G., & Severi, F. (1992). MR of the hypothalamic-pituitary axis in Langerhans cell histiocytosis. American Journal of Neuroradiology, 13(5), 1365-1371.