MR peri-CSF lesions and CSF oligoclonal bands in Italian multiple sclerosis patients

A. Pichiecchio; E. Tavazzi; G. MacCabelli; M. Ponzio; A. Romani; R. Schiappacassa; G. U. Poloni; D. Franciotta; L. Roccatagliata; R. Bergamaschi; S. Bastianello

doi:10.1111/j.1600-0404.2008.01147.x

MR peri-CSF lesions and CSF oligoclonal bands in Italian multiple sclerosis patients

A. Pichiecchio, E. Tavazzi, G. MacCabelli, M. Ponzio, A. Romani, R. Schiappacassa, G. U. Poloni, D. Franciotta, L. Roccatagliata, R. Bergamaschi, S. Bastianello

Research output: Contribution to journal › Article › peer-review

Abstract

Objectives - We investigated the association between brain lesion distribution and the presence of oligoclonal IgG bands (OCBs) in Italian multiple sclerosis (MS) patients. Materials and methods - We retrospectively selected brain magnetic resonance imaging (MRI) uniformly performed in 56 relapsing patients (41 patients OCB positive). Results - Brain lesions in periventricular areas occurred in 92.86% of the patients (100% OCB+ and 73.33% OCB-) (P = 0.004), but we did not find a significant difference for their median volume (P = 0.553) and median number (P = 0.606) between the two groups. Parenchymal lesions occurred in 76.8% of the patients with a similar distribution (P = 1.00) and no significant difference in the median volume (P = 0.818) and number (P = 0.643) between the two groups. Conclusions - The present study on cohort of Italian MS patients demonstrated a lack of correlation between lesion distribution and OCBs, suggesting that B cells producing them could be localized both in meningeal niches and cerebral parenchyma.

Original language	English
Pages (from-to)	242-245
Number of pages	4
Journal	Acta Neurologica Scandinavica
Volume	120
Issue number	4
DOIs	https://doi.org/10.1111/j.1600-0404.2008.01147.x
Publication status	Published - Oct 2009

Keywords

Immunoglobulin G
Magnetic resonance imaging
Multiple sclerosis
Oligoclonal bands

ASJC Scopus subject areas

Clinical Neurology
Neurology

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MR peri-CSF lesions and CSF oligoclonal bands in Italian multiple sclerosis patients. / Pichiecchio, A.; Tavazzi, E.; MacCabelli, G.; Ponzio, M.; Romani, A.; Schiappacassa, R.; Poloni, G. U.; Franciotta, D.; Roccatagliata, L.; Bergamaschi, R.; Bastianello, S.

In: Acta Neurologica Scandinavica, Vol. 120, No. 4, 10.2009, p. 242-245.

Research output: Contribution to journal › Article › peer-review

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abstract = "Objectives - We investigated the association between brain lesion distribution and the presence of oligoclonal IgG bands (OCBs) in Italian multiple sclerosis (MS) patients. Materials and methods - We retrospectively selected brain magnetic resonance imaging (MRI) uniformly performed in 56 relapsing patients (41 patients OCB positive). Results - Brain lesions in periventricular areas occurred in 92.86% of the patients (100% OCB+ and 73.33% OCB-) (P = 0.004), but we did not find a significant difference for their median volume (P = 0.553) and median number (P = 0.606) between the two groups. Parenchymal lesions occurred in 76.8% of the patients with a similar distribution (P = 1.00) and no significant difference in the median volume (P = 0.818) and number (P = 0.643) between the two groups. Conclusions - The present study on cohort of Italian MS patients demonstrated a lack of correlation between lesion distribution and OCBs, suggesting that B cells producing them could be localized both in meningeal niches and cerebral parenchyma.",

keywords = "Immunoglobulin G, Magnetic resonance imaging, Multiple sclerosis, Oligoclonal bands",

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AU - Romani, A.

AU - Schiappacassa, R.

AU - Poloni, G. U.

AU - Franciotta, D.

AU - Roccatagliata, L.

AU - Bergamaschi, R.

AU - Bastianello, S.

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