MR peri-CSF lesions and CSF oligoclonal bands in Italian multiple sclerosis patients

A. Pichiecchio, E. Tavazzi, G. MacCabelli, M. Ponzio, A. Romani, R. Schiappacassa, G. U. Poloni, D. Franciotta, L. Roccatagliata, R. Bergamaschi, S. Bastianello

Research output: Contribution to journalArticlepeer-review

Abstract

Objectives - We investigated the association between brain lesion distribution and the presence of oligoclonal IgG bands (OCBs) in Italian multiple sclerosis (MS) patients. Materials and methods - We retrospectively selected brain magnetic resonance imaging (MRI) uniformly performed in 56 relapsing patients (41 patients OCB positive). Results - Brain lesions in periventricular areas occurred in 92.86% of the patients (100% OCB+ and 73.33% OCB-) (P = 0.004), but we did not find a significant difference for their median volume (P = 0.553) and median number (P = 0.606) between the two groups. Parenchymal lesions occurred in 76.8% of the patients with a similar distribution (P = 1.00) and no significant difference in the median volume (P = 0.818) and number (P = 0.643) between the two groups. Conclusions - The present study on cohort of Italian MS patients demonstrated a lack of correlation between lesion distribution and OCBs, suggesting that B cells producing them could be localized both in meningeal niches and cerebral parenchyma.

Original languageEnglish
Pages (from-to)242-245
Number of pages4
JournalActa Neurologica Scandinavica
Volume120
Issue number4
DOIs
Publication statusPublished - Oct 2009

Keywords

  • Immunoglobulin G
  • Magnetic resonance imaging
  • Multiple sclerosis
  • Oligoclonal bands

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology

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