MR-T2-weighted signal intensity: a new imaging biomarker of prostate cancer aggressiveness

V. Giannini, A. Vignati, S. Mirasole, S. Mazzetti, F. Russo, M. Stasi, D. Regge

Research output: Contribution to journalArticle

Abstract

Prostate cancer (PCa) is the most common solid neoplasm in males and a major cause of cancer-related death. Behaviour of PCa is dichotomous, as patients may either have an indolent clinical course or rapidly progress towards metastatic disease. Unfortunately, biopsy Gleason score (GS) may fail to predict cancer aggressiveness; tumour heterogeneity and inaccurate sampling during biopsy are major causes of underestimation. As a consequence, this frequently results in over-treatment, i.e. low-risk patients overcautiously undergo radical prostatectomy or radiotherapy, frequently with devastating side-effects. Some patients with PCa could be offered a more conservative approach if it were possible to predict patient risk confidently, especially in subjects lying in the grey zone of intermediate risk (i.e. GS = 7), which are in the majority. Recent studies have demonstrated that magnetic resonance (MR) imaging may help improve risk stratification in patients with PCa, providing imaging biomarkers of cancer aggressiveness. The aim of this study is to implement an automatic algorithm pipeline to discriminate different risks of progression from T2-weighted (T2-w) MR imaging. The obtained results confirm that T2-w signal intensity, together with other imaging biomarkers, may represent a new non-invasive approach to assess cancer aggressiveness, potentially helping to plan personalised treatments, and thus dramatically limiting over-diagnosis and over-treatment risks, and reducing the costs for the national healthcare system.

Original languageEnglish
Pages (from-to)130-134
Number of pages5
JournalComputer Methods in Biomechanics and Biomedical Engineering: Imaging and Visualization
Volume4
Issue number3-4
DOIs
Publication statusPublished - Jul 3 2016

Keywords

  • endorectal MR imaging
  • prostate cancer
  • T2-weighted MR images
  • tumour aggressiveness

ASJC Scopus subject areas

  • Biomedical Engineering
  • Radiology Nuclear Medicine and imaging
  • Computational Mechanics
  • Computer Science Applications

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