MR venography in patients with multiple sclerosis and correlation with clinical and MRI parameters

Eytan Raz, Simona Pontecorvo, Veronica Barra, Beatrice Cavallo Marincola, Manuela Morreale, Emanuele Tinelli, Luca Saba, Pier Luigi Di Paolo, Alessandro Aceti, Carlo Catalano, Ada Francia, Francesca Caramia

Research output: Contribution to journalArticle

Abstract

Background and purpose: Multiple sclerosis (MS) has been associated with chronic cerebrospinal venous insufficiency. We aim to evaluate the correlation between extracranial veins stenosis evaluated with MR venography (MRV) and clinical/MR parameters of MS. Methods: In 29 consecutive MS patients we performed a standard brain MRI protocol, completed by the evaluation of extra-cerebral venous system using a phase-contrast and a Volumetric Interpolated Breath Hold Examination (VIBE) sequence before and after gadolinium. The T2-proton density images were used to calculate the lesion volume. The jugular veins were evaluated qualitatively (in terms of presence and severity of stenoses) and quantitatively (degree of stenosis). The phase-contrast images were analyzed to calculate the average and peak velocity in the internal jugular veins. Results: Postcontrast VIBE successfully showed the jugular veins in all the subjects. T2-lesion-volume was 8.2 [4.6] cm3. A stenosis of the internal jugular veins > of 50% was observed in 10/29(33%) patients. No significant correlation was observed between T2-lesion-volume and degree-of-stenosis (r = .362, P = .302). No different flow parameters were found in the subgroups of patients with and without stenosis (P = .54). Conclusions: In MS the presence/severity of jugular vein stenosis identified with 3T-MRV is not related to MR-visible tissue damage. Moreover no abnormal flow parameters were found in stenosed veins.

Original languageEnglish
Pages (from-to)492-497
Number of pages6
JournalJournal of Neuroimaging
Volume24
Issue number5
DOIs
Publication statusPublished - 2014

Fingerprint

Phlebography
Multiple Sclerosis
Pathologic Constriction
Jugular Veins
Veins
Venous Insufficiency
Gadolinium
Protons
Brain

Keywords

  • Brain
  • Gadolinium
  • Jugular veins
  • Magnetic resonance imaging
  • Magnetic resonance venography
  • Multiple sclerosis

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Clinical Neurology
  • Medicine(all)

Cite this

Raz, E., Pontecorvo, S., Barra, V., Marincola, B. C., Morreale, M., Tinelli, E., ... Caramia, F. (2014). MR venography in patients with multiple sclerosis and correlation with clinical and MRI parameters. Journal of Neuroimaging, 24(5), 492-497. https://doi.org/10.1111/jon.12066

MR venography in patients with multiple sclerosis and correlation with clinical and MRI parameters. / Raz, Eytan; Pontecorvo, Simona; Barra, Veronica; Marincola, Beatrice Cavallo; Morreale, Manuela; Tinelli, Emanuele; Saba, Luca; Di Paolo, Pier Luigi; Aceti, Alessandro; Catalano, Carlo; Francia, Ada; Caramia, Francesca.

In: Journal of Neuroimaging, Vol. 24, No. 5, 2014, p. 492-497.

Research output: Contribution to journalArticle

Raz, E, Pontecorvo, S, Barra, V, Marincola, BC, Morreale, M, Tinelli, E, Saba, L, Di Paolo, PL, Aceti, A, Catalano, C, Francia, A & Caramia, F 2014, 'MR venography in patients with multiple sclerosis and correlation with clinical and MRI parameters', Journal of Neuroimaging, vol. 24, no. 5, pp. 492-497. https://doi.org/10.1111/jon.12066
Raz, Eytan ; Pontecorvo, Simona ; Barra, Veronica ; Marincola, Beatrice Cavallo ; Morreale, Manuela ; Tinelli, Emanuele ; Saba, Luca ; Di Paolo, Pier Luigi ; Aceti, Alessandro ; Catalano, Carlo ; Francia, Ada ; Caramia, Francesca. / MR venography in patients with multiple sclerosis and correlation with clinical and MRI parameters. In: Journal of Neuroimaging. 2014 ; Vol. 24, No. 5. pp. 492-497.
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abstract = "Background and purpose: Multiple sclerosis (MS) has been associated with chronic cerebrospinal venous insufficiency. We aim to evaluate the correlation between extracranial veins stenosis evaluated with MR venography (MRV) and clinical/MR parameters of MS. Methods: In 29 consecutive MS patients we performed a standard brain MRI protocol, completed by the evaluation of extra-cerebral venous system using a phase-contrast and a Volumetric Interpolated Breath Hold Examination (VIBE) sequence before and after gadolinium. The T2-proton density images were used to calculate the lesion volume. The jugular veins were evaluated qualitatively (in terms of presence and severity of stenoses) and quantitatively (degree of stenosis). The phase-contrast images were analyzed to calculate the average and peak velocity in the internal jugular veins. Results: Postcontrast VIBE successfully showed the jugular veins in all the subjects. T2-lesion-volume was 8.2 [4.6] cm3. A stenosis of the internal jugular veins > of 50{\%} was observed in 10/29(33{\%}) patients. No significant correlation was observed between T2-lesion-volume and degree-of-stenosis (r = .362, P = .302). No different flow parameters were found in the subgroups of patients with and without stenosis (P = .54). Conclusions: In MS the presence/severity of jugular vein stenosis identified with 3T-MRV is not related to MR-visible tissue damage. Moreover no abnormal flow parameters were found in stenosed veins.",
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AU - Morreale, Manuela

AU - Tinelli, Emanuele

AU - Saba, Luca

AU - Di Paolo, Pier Luigi

AU - Aceti, Alessandro

AU - Catalano, Carlo

AU - Francia, Ada

AU - Caramia, Francesca

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N2 - Background and purpose: Multiple sclerosis (MS) has been associated with chronic cerebrospinal venous insufficiency. We aim to evaluate the correlation between extracranial veins stenosis evaluated with MR venography (MRV) and clinical/MR parameters of MS. Methods: In 29 consecutive MS patients we performed a standard brain MRI protocol, completed by the evaluation of extra-cerebral venous system using a phase-contrast and a Volumetric Interpolated Breath Hold Examination (VIBE) sequence before and after gadolinium. The T2-proton density images were used to calculate the lesion volume. The jugular veins were evaluated qualitatively (in terms of presence and severity of stenoses) and quantitatively (degree of stenosis). The phase-contrast images were analyzed to calculate the average and peak velocity in the internal jugular veins. Results: Postcontrast VIBE successfully showed the jugular veins in all the subjects. T2-lesion-volume was 8.2 [4.6] cm3. A stenosis of the internal jugular veins > of 50% was observed in 10/29(33%) patients. No significant correlation was observed between T2-lesion-volume and degree-of-stenosis (r = .362, P = .302). No different flow parameters were found in the subgroups of patients with and without stenosis (P = .54). Conclusions: In MS the presence/severity of jugular vein stenosis identified with 3T-MRV is not related to MR-visible tissue damage. Moreover no abnormal flow parameters were found in stenosed veins.

AB - Background and purpose: Multiple sclerosis (MS) has been associated with chronic cerebrospinal venous insufficiency. We aim to evaluate the correlation between extracranial veins stenosis evaluated with MR venography (MRV) and clinical/MR parameters of MS. Methods: In 29 consecutive MS patients we performed a standard brain MRI protocol, completed by the evaluation of extra-cerebral venous system using a phase-contrast and a Volumetric Interpolated Breath Hold Examination (VIBE) sequence before and after gadolinium. The T2-proton density images were used to calculate the lesion volume. The jugular veins were evaluated qualitatively (in terms of presence and severity of stenoses) and quantitatively (degree of stenosis). The phase-contrast images were analyzed to calculate the average and peak velocity in the internal jugular veins. Results: Postcontrast VIBE successfully showed the jugular veins in all the subjects. T2-lesion-volume was 8.2 [4.6] cm3. A stenosis of the internal jugular veins > of 50% was observed in 10/29(33%) patients. No significant correlation was observed between T2-lesion-volume and degree-of-stenosis (r = .362, P = .302). No different flow parameters were found in the subgroups of patients with and without stenosis (P = .54). Conclusions: In MS the presence/severity of jugular vein stenosis identified with 3T-MRV is not related to MR-visible tissue damage. Moreover no abnormal flow parameters were found in stenosed veins.

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