MRI and cognitive patterns in relapsing-remitting multiple sclerosis

Luigi Pugnetti, Laura Mendozzi, Achille Motta, Annamaria Cattaneo, Paolo Biserni, Domenico Caputo, Carlo L. Cazzullo, Frida Valsecchi

Research output: Contribution to journalArticle

Abstract

We studied the relationships between magnetic resonance imaging (MRI) and the Luria-Nebraska Neuropsychological Battery (LNNB) in 64 patients with relapsing-remitting multiple sclerosis (MS). MRI films were scored according to arbitrary descriptive criteria designed to emphasize patterns of alterations. Five groups were created: group 1 and 2 had typical discrete white matter lesions, group 3 had confluent lesions, group 4 had large discrete lesions and group 5 had only few small lesions. In addition, groups 2 and 3 had evidence of parenchymal atrophy. Groups 2 and 3 were the most impaired on the LNNB, but none of these patients was actually demented. Groups 1 and 5 were globally intact in spite of very different mean age and MRI pattern. Group 4 was composed of younger subjects with a shorter disease duration; they showed mild loss of attentive and abstracting abilities. We suggest that since their MRI was showing greater signs of local biological activity their mental deficits may be a transitory condition capable of two distinct outcomes: a favorable one as in groups 1 and 5, and a slowly progressive one associated with loss of brain tissue as in groups 2 and 3.

Original languageEnglish
JournalJournal of the Neurological Sciences
Volume115
Issue numberSUPPL.
DOIs
Publication statusPublished - 1993

Fingerprint

Relapsing-Remitting Multiple Sclerosis
Luria-Nebraska Neuropsychological Battery
Magnetic Resonance Imaging
Aptitude
Atrophy
Brain

Keywords

  • Brain magnetic resonance imaging
  • Cognition
  • Multiple sclerosis

ASJC Scopus subject areas

  • Ageing
  • Clinical Neurology
  • Surgery
  • Neuroscience(all)
  • Developmental Neuroscience
  • Neurology

Cite this

MRI and cognitive patterns in relapsing-remitting multiple sclerosis. / Pugnetti, Luigi; Mendozzi, Laura; Motta, Achille; Cattaneo, Annamaria; Biserni, Paolo; Caputo, Domenico; Cazzullo, Carlo L.; Valsecchi, Frida.

In: Journal of the Neurological Sciences, Vol. 115, No. SUPPL., 1993.

Research output: Contribution to journalArticle

Pugnetti, Luigi ; Mendozzi, Laura ; Motta, Achille ; Cattaneo, Annamaria ; Biserni, Paolo ; Caputo, Domenico ; Cazzullo, Carlo L. ; Valsecchi, Frida. / MRI and cognitive patterns in relapsing-remitting multiple sclerosis. In: Journal of the Neurological Sciences. 1993 ; Vol. 115, No. SUPPL.
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