MRI as a tool for non-invasive vascular profiling: A pilot study in patients with aortic coarctation

Marcus Kelm, Leonid Goubergrits, Joao Filipe Fernandes, Lucio Biocca, Giacomo Pongiglione, Vivek Muthurangu, Abbas Khushnood, Aurelio Secinaro, Marcello Chinali, Stephan Schubert, Felix Berger, Titus Kuehne

Research output: Contribution to journalArticlepeer-review

Abstract

Aim: While the overall concept of aortic coarctation has changed from one of simple obstruction to one that includes significant vascular dysfunction, this has not yet been translated into the diagnostic and treatment process. To close this gap, we sought to demonstrate the usefulness of an additional non-invasive vascular profile. Method: During a pilot study in eight coarctation patients, aortic area compliance, aortic distensibility, time phase shift and blood flow (distribution) were calculated from cine-MRI and 2D-/4D-velocity-encoded MRI sequences. Results: Compared to healthy individuals, a significantly lower aortic compliance and reduced flow to the descending aorta were found in patients with coarctation. Discussion: These differences underline the potential usefulness of a combined vascular profile in coarctation patients. Conclusion: It was successfully shown that functional vascular profiling of the aorta is feasible to be acquired non-invasively in a clinical setting and can provide additional diagnostic information. These can be the key input parameters for computational fluid dynamics-modeling.

Original languageEnglish
Pages (from-to)103-112
Number of pages10
JournalExpert Review of Medical Devices
Volume13
Issue number1
DOIs
Publication statusPublished - Jan 2 2016

Keywords

  • aortic coarctation
  • aortic compliance
  • aortic perfusion
  • cardiac MRI
  • catheterization
  • congenital heart disease
  • disease modeling
  • vascular auto-regulation
  • Windkessel function

ASJC Scopus subject areas

  • Surgery
  • Biomedical Engineering

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