TY - JOUR
T1 - MRI assessment of bone marrow in children with juvenile idiopathic arthritis
T2 - Intra-and inter-observer variability
AU - De Horatio, Laura Tanturri
AU - Damasio, Maria Beatrice
AU - Barbuti, Domenico
AU - Bracaglia, Claudia
AU - Lambot-Juhan, Karen
AU - Boavida, Peter
AU - Müller, Lil Sofie Ording
AU - Malattia, Clara
AU - Ravà, Lucilla
AU - Rosendahl, Karen
AU - Tomà, Paolo
PY - 2012/6
Y1 - 2012/6
N2 - Background Bone marrow oedema (BMO) is included in MRI-based scoring systems of disease activity in adults with rheumatoid arthritis. Similar systems in juvenile idiopathic arthritis (JIA) are lacking. Objective To assess the reproducibility in a multi-centre setting of an MRI BMO scoring system in children with JIA. Materials and methods Seventy-six wrist MRIs were read twice, independently, by two experienced paediatric radiologists. BMO was defined as ill-defined lesions within the trabecular bone, returning high and low signal on T2-and T1-weighted images respectively, with or without contrast enhancement. BMO extension was scored for each of 14 bones at the wrist from 0 (none) to 3 (extensive). Results The intra-observer agreement was moderate to excellent, with weighted kappa ranging from 0.85 to 1.0 and 0.49 to 1.0 (readers 1 and 2 respectively), while the interobserver agreement ranged from 0.41 to 0.79. The intra-and inter-observer intraclass correlation coefficients were excellent and satisfactory, respectively. Conclusion The scoring system was reliable and may be used for grading bone marrow abnormality in JIA. The relatively large variability in aggregate scores, particularly between readers, underscores the need for thorough standardisation.
AB - Background Bone marrow oedema (BMO) is included in MRI-based scoring systems of disease activity in adults with rheumatoid arthritis. Similar systems in juvenile idiopathic arthritis (JIA) are lacking. Objective To assess the reproducibility in a multi-centre setting of an MRI BMO scoring system in children with JIA. Materials and methods Seventy-six wrist MRIs were read twice, independently, by two experienced paediatric radiologists. BMO was defined as ill-defined lesions within the trabecular bone, returning high and low signal on T2-and T1-weighted images respectively, with or without contrast enhancement. BMO extension was scored for each of 14 bones at the wrist from 0 (none) to 3 (extensive). Results The intra-observer agreement was moderate to excellent, with weighted kappa ranging from 0.85 to 1.0 and 0.49 to 1.0 (readers 1 and 2 respectively), while the interobserver agreement ranged from 0.41 to 0.79. The intra-and inter-observer intraclass correlation coefficients were excellent and satisfactory, respectively. Conclusion The scoring system was reliable and may be used for grading bone marrow abnormality in JIA. The relatively large variability in aggregate scores, particularly between readers, underscores the need for thorough standardisation.
KW - Bone marrow oedema
KW - Juvenile idiopathic arthritis .Wrist
KW - MRI
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U2 - 10.1007/s00247-012-2345-y
DO - 10.1007/s00247-012-2345-y
M3 - Article
C2 - 22426566
AN - SCOPUS:84863930161
VL - 42
SP - 714
EP - 720
JO - Pediatric Radiology
JF - Pediatric Radiology
SN - 0301-0449
IS - 6
ER -