MRI characterization of myocardial tissue in patients with Fabry's disease

Massimo Imbriaco, Letizia Spinelli, Alberto Cuocolo, Simone Maurea, Giacomo Sica, Mario Quarantelli, Antonio Pisani, Raffaele Liuzzi, Bruno Cianciaruso, Massimo Sabbatini, Marco Salvatore

Research output: Contribution to journalArticlepeer-review

Abstract

OBJECTIVE. Fabry's disease is a multisystem X-linked disorder of lysosomal metabolism frequently associated with left ventricular (LV) hypertrophy. In this study, we aimed to assess whether myocardial T2 relaxation time determined by a black blood multiecho multishot MRI sequence could be used to evaluate cardiac involvement in patients with Fabry's disease. CONCLUSION. Myocardial T2 relaxation time is prolonged in patients with Fabry's disease compared with that of hypertrophic patients and healthy control subjects. MRI may be useful for the characterization of myocardial tissue in patients with Fabry's disease.

Original languageEnglish
Pages (from-to)850-853
Number of pages4
JournalAmerican Journal of Roentgenology
Volume188
Issue number3
DOIs
Publication statusPublished - Mar 2007

Keywords

  • Cardiac imaging
  • Cardiovascular disease
  • Cerebrovascular disease
  • Fabry's disease
  • MRI
  • Renal disease
  • T2 relaxation time

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology

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