TY - JOUR
T1 - MRI-Derived Biomarkers Related to Sarcopenia
T2 - A Systematic Review
AU - Codari, Marina
AU - Zanardo, Moreno
AU - di Sabato, Maria Eugenia
AU - Nocerino, Elisabetta
AU - Messina, Carmelo
AU - Sconfienza, Luca Maria
AU - Sardanelli, Francesco
PY - 2019/1/1
Y1 - 2019/1/1
N2 - Background: MRI allows quantitatively assessing muscle quantity and quality. Purpose: To summarize the role of MRI as a noninvasive technique for the identification of in vivo surrogate biomarker of sarcopenia. Study Type: Systematic review. Population: In April 2019, a systematic literature search (Medline/EMBASE) was performed to identify articles on the topic at issue. Field Strength/Sequence: No field strength or sequence restrictions. Assessment: After a literature search, study design, aim, sample size, demographics, magnetic field strength, imaged body region, MRI sequences, and imaging biomarker were extracted. Statistical Tests: Data are presented as frequencies and percentages. Results: From 69 records identified through search query, 18 articles matched the inclusion criteria. All articles were published from 2012 and had a mainly prospective design (14/18, 78%). Sample size ranged from 9 to 284 subjects, for a total of 1706 enrolled subjects. Healthy subjects were enrolled or retrospectively selected in 8/18 (44%) articles, corresponding to 658 (39%) healthy subjects. Magnetic field strength was 1.5 or 3T in 14/18 (78%) studies. The most analyzed body regions were the thigh (7/18, 39%) and the trunk (6/18, 33%). Stratifying studies according to their aim, 13/18 (72%) studies focused on muscle quality and quantity, 3/18 (17%) studies on outcome prediction, and 2/18 articles (11%) addressed both aims. A wide set of MRI biomarkers have been proposed. Muscle cross-sectional area was the most used for muscle quantity estimation, while quantitative biomarkers of muscle fat content or fiber architecture were proposed to assess muscle quality. Data Conclusion: The proposed biomarkers were assessed using different MRI sequences for different body regions in different subjects/patient cohorts, pointing out a lack of standardization on this topic. Future studies should test and compare the performance of proposed MRI biomarkers for sarcopenia characterization and quantification using a standardized experimental setup. Level of Evidence: 1. Technical Efficacy Stage: 2.
AB - Background: MRI allows quantitatively assessing muscle quantity and quality. Purpose: To summarize the role of MRI as a noninvasive technique for the identification of in vivo surrogate biomarker of sarcopenia. Study Type: Systematic review. Population: In April 2019, a systematic literature search (Medline/EMBASE) was performed to identify articles on the topic at issue. Field Strength/Sequence: No field strength or sequence restrictions. Assessment: After a literature search, study design, aim, sample size, demographics, magnetic field strength, imaged body region, MRI sequences, and imaging biomarker were extracted. Statistical Tests: Data are presented as frequencies and percentages. Results: From 69 records identified through search query, 18 articles matched the inclusion criteria. All articles were published from 2012 and had a mainly prospective design (14/18, 78%). Sample size ranged from 9 to 284 subjects, for a total of 1706 enrolled subjects. Healthy subjects were enrolled or retrospectively selected in 8/18 (44%) articles, corresponding to 658 (39%) healthy subjects. Magnetic field strength was 1.5 or 3T in 14/18 (78%) studies. The most analyzed body regions were the thigh (7/18, 39%) and the trunk (6/18, 33%). Stratifying studies according to their aim, 13/18 (72%) studies focused on muscle quality and quantity, 3/18 (17%) studies on outcome prediction, and 2/18 articles (11%) addressed both aims. A wide set of MRI biomarkers have been proposed. Muscle cross-sectional area was the most used for muscle quantity estimation, while quantitative biomarkers of muscle fat content or fiber architecture were proposed to assess muscle quality. Data Conclusion: The proposed biomarkers were assessed using different MRI sequences for different body regions in different subjects/patient cohorts, pointing out a lack of standardization on this topic. Future studies should test and compare the performance of proposed MRI biomarkers for sarcopenia characterization and quantification using a standardized experimental setup. Level of Evidence: 1. Technical Efficacy Stage: 2.
KW - biomarkers
KW - magnetic resonance imaging
KW - prognosis
KW - quantitative MRI
KW - sarcopenia
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U2 - 10.1002/jmri.26931
DO - 10.1002/jmri.26931
M3 - Article
C2 - 31515891
AN - SCOPUS:85073794999
JO - Journal of Magnetic Resonance Imaging
JF - Journal of Magnetic Resonance Imaging
SN - 1053-1807
ER -