MRI evaluation of sacral chordoma treated with carbon ion radiotherapy alone

Lorenzo Preda, Davide Stoppa, Maria Rosaria Fiore, Giulia Fontana, Sofia Camisa, Roberto Sacchi, Michele Ghitti, Gisela Viselner, Piero Fossati, Francesca Valvo, Viviana Vitolo, Maria Bonora, Alberto Iannalfi, Barbara Vischioni, Alessandro Vai, Edoardo Mastella, Guido Baroni, Roberto Orecchia

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Background and purpose: To compare RECIST 1.1 with volume modifications in patients with sacral chordoma not suitable for surgery treated with carbon ions radiotherapy (CIRT) alone. To evaluate patients pain before and after CIRT. To detect if baseline Apparent Diffusion Coefficient values (ADC) from Diffusion Weighted sequences could predict response to treatment. Material and methods: Patients included had one cycle of CIRT and underwent MRI before and after treatment. For each MRI, lesion maximum diameter and volume were obtained, and ADC values were analyzed within the whole lesion volume. Patients pain was evaluated with Numerical Rating Scale (NRS), considering the upper tumor level at baseline MRIs. Results: 39 patients were studied (mean follow-up 18 months). Considering RECIST 1.1 there was not a significant reduction in tumor diameters (p = 0.19), instead there was a significant reduction in tumor volume (p < 0.001), with a significant reduction in pain (p = 0.021) if the tumors were above vertebrae S2-S3 at baseline MRIs. The assessment of baseline ADC maps demonstrated higher median values and more negative skewness values in progressive disease (PD) patients versus both partial response (PR) and stable disease (SD). Conclusions: Lesion volume measurement is more accurate than maximum diameter to better stratify the response of sacral chordoma treated with CIRT. Preliminary results suggest that baseline ADC values could be predictive of response to CIRT.

Original languageEnglish
JournalRadiotherapy and Oncology
DOIs
Publication statusAccepted/In press - Jan 1 2017

Fingerprint

Heavy Ion Radiotherapy
Chordoma
Pain
Neoplasms
Tumor Burden
Spine
Therapeutics

Keywords

  • Carbon ion radiotherapy
  • Diffusion Weighted MRI
  • Magnetic resonance
  • RECIST 1.1
  • Sacral chordoma

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Radiology Nuclear Medicine and imaging

Cite this

MRI evaluation of sacral chordoma treated with carbon ion radiotherapy alone. / Preda, Lorenzo; Stoppa, Davide; Fiore, Maria Rosaria; Fontana, Giulia; Camisa, Sofia; Sacchi, Roberto; Ghitti, Michele; Viselner, Gisela; Fossati, Piero; Valvo, Francesca; Vitolo, Viviana; Bonora, Maria; Iannalfi, Alberto; Vischioni, Barbara; Vai, Alessandro; Mastella, Edoardo; Baroni, Guido; Orecchia, Roberto.

In: Radiotherapy and Oncology, 01.01.2017.

Research output: Contribution to journalArticle

Preda, L, Stoppa, D, Fiore, MR, Fontana, G, Camisa, S, Sacchi, R, Ghitti, M, Viselner, G, Fossati, P, Valvo, F, Vitolo, V, Bonora, M, Iannalfi, A, Vischioni, B, Vai, A, Mastella, E, Baroni, G & Orecchia, R 2017, 'MRI evaluation of sacral chordoma treated with carbon ion radiotherapy alone', Radiotherapy and Oncology. https://doi.org/10.1016/j.radonc.2017.11.029
Preda, Lorenzo ; Stoppa, Davide ; Fiore, Maria Rosaria ; Fontana, Giulia ; Camisa, Sofia ; Sacchi, Roberto ; Ghitti, Michele ; Viselner, Gisela ; Fossati, Piero ; Valvo, Francesca ; Vitolo, Viviana ; Bonora, Maria ; Iannalfi, Alberto ; Vischioni, Barbara ; Vai, Alessandro ; Mastella, Edoardo ; Baroni, Guido ; Orecchia, Roberto. / MRI evaluation of sacral chordoma treated with carbon ion radiotherapy alone. In: Radiotherapy and Oncology. 2017.
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author = "Lorenzo Preda and Davide Stoppa and Fiore, {Maria Rosaria} and Giulia Fontana and Sofia Camisa and Roberto Sacchi and Michele Ghitti and Gisela Viselner and Piero Fossati and Francesca Valvo and Viviana Vitolo and Maria Bonora and Alberto Iannalfi and Barbara Vischioni and Alessandro Vai and Edoardo Mastella and Guido Baroni and Roberto Orecchia",
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AU - Preda, Lorenzo

AU - Stoppa, Davide

AU - Fiore, Maria Rosaria

AU - Fontana, Giulia

AU - Camisa, Sofia

AU - Sacchi, Roberto

AU - Ghitti, Michele

AU - Viselner, Gisela

AU - Fossati, Piero

AU - Valvo, Francesca

AU - Vitolo, Viviana

AU - Bonora, Maria

AU - Iannalfi, Alberto

AU - Vischioni, Barbara

AU - Vai, Alessandro

AU - Mastella, Edoardo

AU - Baroni, Guido

AU - Orecchia, Roberto

PY - 2017/1/1

Y1 - 2017/1/1

N2 - Background and purpose: To compare RECIST 1.1 with volume modifications in patients with sacral chordoma not suitable for surgery treated with carbon ions radiotherapy (CIRT) alone. To evaluate patients pain before and after CIRT. To detect if baseline Apparent Diffusion Coefficient values (ADC) from Diffusion Weighted sequences could predict response to treatment. Material and methods: Patients included had one cycle of CIRT and underwent MRI before and after treatment. For each MRI, lesion maximum diameter and volume were obtained, and ADC values were analyzed within the whole lesion volume. Patients pain was evaluated with Numerical Rating Scale (NRS), considering the upper tumor level at baseline MRIs. Results: 39 patients were studied (mean follow-up 18 months). Considering RECIST 1.1 there was not a significant reduction in tumor diameters (p = 0.19), instead there was a significant reduction in tumor volume (p < 0.001), with a significant reduction in pain (p = 0.021) if the tumors were above vertebrae S2-S3 at baseline MRIs. The assessment of baseline ADC maps demonstrated higher median values and more negative skewness values in progressive disease (PD) patients versus both partial response (PR) and stable disease (SD). Conclusions: Lesion volume measurement is more accurate than maximum diameter to better stratify the response of sacral chordoma treated with CIRT. Preliminary results suggest that baseline ADC values could be predictive of response to CIRT.

AB - Background and purpose: To compare RECIST 1.1 with volume modifications in patients with sacral chordoma not suitable for surgery treated with carbon ions radiotherapy (CIRT) alone. To evaluate patients pain before and after CIRT. To detect if baseline Apparent Diffusion Coefficient values (ADC) from Diffusion Weighted sequences could predict response to treatment. Material and methods: Patients included had one cycle of CIRT and underwent MRI before and after treatment. For each MRI, lesion maximum diameter and volume were obtained, and ADC values were analyzed within the whole lesion volume. Patients pain was evaluated with Numerical Rating Scale (NRS), considering the upper tumor level at baseline MRIs. Results: 39 patients were studied (mean follow-up 18 months). Considering RECIST 1.1 there was not a significant reduction in tumor diameters (p = 0.19), instead there was a significant reduction in tumor volume (p < 0.001), with a significant reduction in pain (p = 0.021) if the tumors were above vertebrae S2-S3 at baseline MRIs. The assessment of baseline ADC maps demonstrated higher median values and more negative skewness values in progressive disease (PD) patients versus both partial response (PR) and stable disease (SD). Conclusions: Lesion volume measurement is more accurate than maximum diameter to better stratify the response of sacral chordoma treated with CIRT. Preliminary results suggest that baseline ADC values could be predictive of response to CIRT.

KW - Carbon ion radiotherapy

KW - Diffusion Weighted MRI

KW - Magnetic resonance

KW - RECIST 1.1

KW - Sacral chordoma

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