Abstract
Objective - To investigate the evolution of multiple sclerosis (MS) lesions enhancing after single dose (SD) or triple dose (TD) of gadolinium- DTPA (Gd). Material and methods - For 3 months, 30 relapsing-remitting MS patients underwent 2 monthly MRI sessions, consisting of Gd-enhanced T1- weighted scans, after SD (i.e., 0.1 mmol/kg) in one session and TD (i.e., 0.3 mmol/kg) in the other. New enhancing lesions on month 1 and month 2 follow- up scans were studied and for them any persistence of enhancement was evaluated on the scans obtained the next month. Results - In all, 151 lesions enhancing after both SD and TD and 91 lesions enhancing only after TD entered the analysis. After 1 month, for the 151 lesions enhancing after both SD and TD, 73 (48%) were not enhancing, 50 (33%) were still enhancing after both SD and TD and 28 (19%) were enhancing only after TD. For the 91 lesions enhancing only after TD, 61 (67%; P
Original language | English |
---|---|
Pages (from-to) | 90-93 |
Number of pages | 4 |
Journal | Acta Neurologica Scandinavica |
Volume | 98 |
Issue number | 2 |
Publication status | Published - 1998 |
Keywords
- Blood- brain barrier permeability
- Gadolinium-DTPA
- Magnetic resonance imaging
- Multiple sclerosis
ASJC Scopus subject areas
- Clinical Neurology
- Neuroscience(all)