MRI features of cerebral lesions and cognitive functions in preterm spastic diplegic children

Ermellina Fedrizzi, Michelina Inverno, Maria Grazia Bruzzone, Gabriella Botteon, Veronica Saletti, Mariangela Farinotti

Research output: Contribution to journalArticle

Abstract

The aim of this study is to further clarify the relation between the pattern of cognitive impairment in spastic diplegic children horn preterm and MRI features of cerebral lesions. The cognitive profile by Wechsler Scale of a sample of 30 children aged 6 years, 8 months to 14 years, 7 months was assessed, and the correlations between the Full Scale, Verbal, and Performance IQ and periventricular leukomalacia features on MRI were investigated. A significant difference was observed between the mean Verbal and Performance IQ, indicating a specific failure in the visuoperceptual functions of spastic diplegic children born preterm. Periventricular leukomalacia was detected in all children. The severity of ventricular dilatation, the degree and extent of white matter reduction, optic radiation involvement, and the thinning of the posterior corpus callosum correlated significantly with the Full Scale and Performance IQ; no correlation was observed between the Verbal IQ and any of the MRI features analyzed. In spastic diplegic children, an MRI examination between the ages of 1 and 2 years may be helpful in predicting a specific neuropsychological pattern of dysfunction and in defining an early intervention program.

Original languageEnglish
Pages (from-to)207-212
Number of pages6
JournalPediatric Neurology
Volume15
Issue number3
DOIs
Publication statusPublished - Oct 1996

Fingerprint

Muscle Spasticity
Cognition
Periventricular Leukomalacia
Wechsler Scales
Corpus Callosum
Horns
Dilatation
Radiation

ASJC Scopus subject areas

  • Clinical Neurology
  • Pediatrics, Perinatology, and Child Health
  • Developmental Neuroscience
  • Neurology

Cite this

MRI features of cerebral lesions and cognitive functions in preterm spastic diplegic children. / Fedrizzi, Ermellina; Inverno, Michelina; Bruzzone, Maria Grazia; Botteon, Gabriella; Saletti, Veronica; Farinotti, Mariangela.

In: Pediatric Neurology, Vol. 15, No. 3, 10.1996, p. 207-212.

Research output: Contribution to journalArticle

@article{e49ddb54ecf34f70aaa0a1c06c19ae9b,
title = "MRI features of cerebral lesions and cognitive functions in preterm spastic diplegic children",
abstract = "The aim of this study is to further clarify the relation between the pattern of cognitive impairment in spastic diplegic children horn preterm and MRI features of cerebral lesions. The cognitive profile by Wechsler Scale of a sample of 30 children aged 6 years, 8 months to 14 years, 7 months was assessed, and the correlations between the Full Scale, Verbal, and Performance IQ and periventricular leukomalacia features on MRI were investigated. A significant difference was observed between the mean Verbal and Performance IQ, indicating a specific failure in the visuoperceptual functions of spastic diplegic children born preterm. Periventricular leukomalacia was detected in all children. The severity of ventricular dilatation, the degree and extent of white matter reduction, optic radiation involvement, and the thinning of the posterior corpus callosum correlated significantly with the Full Scale and Performance IQ; no correlation was observed between the Verbal IQ and any of the MRI features analyzed. In spastic diplegic children, an MRI examination between the ages of 1 and 2 years may be helpful in predicting a specific neuropsychological pattern of dysfunction and in defining an early intervention program.",
author = "Ermellina Fedrizzi and Michelina Inverno and Bruzzone, {Maria Grazia} and Gabriella Botteon and Veronica Saletti and Mariangela Farinotti",
year = "1996",
month = "10",
doi = "10.1016/S0887-8994(96)00174-9",
language = "English",
volume = "15",
pages = "207--212",
journal = "Pediatric Neurology",
issn = "0887-8994",
publisher = "Elsevier Inc.",
number = "3",

}

TY - JOUR

T1 - MRI features of cerebral lesions and cognitive functions in preterm spastic diplegic children

AU - Fedrizzi, Ermellina

AU - Inverno, Michelina

AU - Bruzzone, Maria Grazia

AU - Botteon, Gabriella

AU - Saletti, Veronica

AU - Farinotti, Mariangela

PY - 1996/10

Y1 - 1996/10

N2 - The aim of this study is to further clarify the relation between the pattern of cognitive impairment in spastic diplegic children horn preterm and MRI features of cerebral lesions. The cognitive profile by Wechsler Scale of a sample of 30 children aged 6 years, 8 months to 14 years, 7 months was assessed, and the correlations between the Full Scale, Verbal, and Performance IQ and periventricular leukomalacia features on MRI were investigated. A significant difference was observed between the mean Verbal and Performance IQ, indicating a specific failure in the visuoperceptual functions of spastic diplegic children born preterm. Periventricular leukomalacia was detected in all children. The severity of ventricular dilatation, the degree and extent of white matter reduction, optic radiation involvement, and the thinning of the posterior corpus callosum correlated significantly with the Full Scale and Performance IQ; no correlation was observed between the Verbal IQ and any of the MRI features analyzed. In spastic diplegic children, an MRI examination between the ages of 1 and 2 years may be helpful in predicting a specific neuropsychological pattern of dysfunction and in defining an early intervention program.

AB - The aim of this study is to further clarify the relation between the pattern of cognitive impairment in spastic diplegic children horn preterm and MRI features of cerebral lesions. The cognitive profile by Wechsler Scale of a sample of 30 children aged 6 years, 8 months to 14 years, 7 months was assessed, and the correlations between the Full Scale, Verbal, and Performance IQ and periventricular leukomalacia features on MRI were investigated. A significant difference was observed between the mean Verbal and Performance IQ, indicating a specific failure in the visuoperceptual functions of spastic diplegic children born preterm. Periventricular leukomalacia was detected in all children. The severity of ventricular dilatation, the degree and extent of white matter reduction, optic radiation involvement, and the thinning of the posterior corpus callosum correlated significantly with the Full Scale and Performance IQ; no correlation was observed between the Verbal IQ and any of the MRI features analyzed. In spastic diplegic children, an MRI examination between the ages of 1 and 2 years may be helpful in predicting a specific neuropsychological pattern of dysfunction and in defining an early intervention program.

UR - http://www.scopus.com/inward/record.url?scp=0030273453&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0030273453&partnerID=8YFLogxK

U2 - 10.1016/S0887-8994(96)00174-9

DO - 10.1016/S0887-8994(96)00174-9

M3 - Article

C2 - 8916157

AN - SCOPUS:0030273453

VL - 15

SP - 207

EP - 212

JO - Pediatric Neurology

JF - Pediatric Neurology

SN - 0887-8994

IS - 3

ER -