Mri in hypertrophie cardiomyopathy: A morphofunctional study

Francesco Sardanelli, Giuseppe Molinari, Aldo Petillo, Carlo Ottonello, Roberto C. Parodi, Maria A. Masperone, Sandro Saitta, Massimiliano Basso, Salvatore Caponnetto

Research output: Contribution to journalArticlepeer-review


Objective: We compared MRI with two-dimensional echocardiography (2dE) and Doppler echocardiography to determine the diagnostic role of MRI in hypertrophic cardiomyopathy (HCM). Materials and Methods: Twenty-three patients with 2dE diagnosis of HCM were examined with MRI; 12 of 23 patients were also studied by color (cDE) and continuous wave (cwDE) Doppler echocardiography. Morphologie information and diastolic heart wall thickness were obtained by SE sequences; functional study was performed by gradient echo sequences (eine MR). Results: The correlation between MR, SE sequences and 2dE was better for septal (r = 0.930, p <0.01) than for posterolateral (r = 0.739, p <0.01) wall thickness. The assessment of the distribution of the hypertrophy was changed by MR in five cases. Cine MR functional study showed a systolic subaortic signal void (dynamic obstruction) in 12 of 22 patients and a systolic left atrial Signal void (mitral regurgitation) in 17 of 22. Systolic wall thickening was studied by cine MR and 2dE in 11 patients: A good correlation was found for septum (0.01 <P <0.05) and a poor one for posterolateral wall (p > 0.05). The cine MR and cDE turbulence duration in the left ventricle and atrium showed excellent correlation (p <0.01). Good agreement was found between the duration of subaortic turbulence (cine MR or cDE) and the pressure gradient (cwDE) (p <0.01 and 0.01 <p <0.05, respectively) and between cine MR and cDE semiquantitative estimate of the mitral regurgitation (p <0.01). In all patients with subaortic MR signal void studied with cwDE, a pressure gradient was present. Conclusion: Magnetic resonance imaging can play an important role in the diagnosis of HCM after 2dE-DE.

Original languageEnglish
Pages (from-to)862-872
Number of pages11
JournalJournal of Computer Assisted Tomography
Issue number6
Publication statusPublished - 1993


  • Cine
  • Diseases
  • Flow dynamics
  • Heart
  • Heart
  • Magnetic resonance imaging

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology


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