MRI in identifying hepatic steatosis in obese children and relation to ultrasonography and metabolic findings

Carlo Pozzato, Giovanni Radaelli, Chiara Dall'Asta, Elvira Verduci, Anna Villa, Chiara Villa, Silvia Scaglioni, Enrica Riva, Antonio E. Pontiroli, Gianpaolo Cornalba, Marcello Giovannini

Research output: Contribution to journalArticle

Abstract

Objectives: The aim of this study was to identify nonalcoholic fatty liver in obese children by magnetic resonance imaging (MRI) and to compare the findings with the data from ultrasonography and from clinical and laboratory testing. Patients and Methods: Sixty obese children, 6 to 14 years old, underwent hepatic MRI and abdominal ultrasonography. Biochemistry determinations included serum aminotransferases, lipid profile, glucose, and insulin. Anthropometry included body mass index, total and trunk fat, and fat-free mass obtained by dual-energy radiographic absorptiometry. Hepatic steatosis, judged as hepatic fat fraction by MRI, was ≥9%. Results: By MRI, 14 (23%) children had hepatic steatosis; of those, 5 had a fat fraction of 9% to 18%, and 9 had a fat fraction >18%. At univariate analysis, fat fraction was positively associated with being male, serum alanine aminotransferase, aspartate aminotransferase, and γ-glutamyltransferase, body mass index z score, insulin, systolic pressure, and total and trunk fat mass. Hepatic steatosis was independently associated with alanine aminotransferase (P18%. All of the children (n=9) with fat fraction ≥18% had increased liver echogenicity, and in 8 of them it was graded 2 or 3, but the MRI fat fraction ranged greatly (28%-45%). Conclusions: In obese children, nonalcoholic hepatic steatosis may be associated with the metabolic syndrome. Ultrasonography may be valuable in identifying high hepatic fat accumulation, but its ability to identify lower fat accumulation in the liver is scanty compared with MRI. JPGN 47:493-499, 2008.

Original languageEnglish
Pages (from-to)493-499
Number of pages7
JournalJournal of Pediatric Gastroenterology and Nutrition
Volume47
Issue number4
Publication statusPublished - Oct 2008

Fingerprint

Ultrasonography
Fats
Magnetic Resonance Imaging
Liver
Alanine Transaminase
Body Mass Index
Insulin
Anthropometry
Photon Absorptiometry
Aspartate Aminotransferases
Transaminases
Serum
Biochemistry
Blood Pressure
Lipids
Glucose

Keywords

  • Chemical-shift magnetic resonance imaging
  • Fatty liver
  • Obesity
  • Ultrasound

ASJC Scopus subject areas

  • Gastroenterology
  • Pediatrics, Perinatology, and Child Health

Cite this

Pozzato, C., Radaelli, G., Dall'Asta, C., Verduci, E., Villa, A., Villa, C., ... Giovannini, M. (2008). MRI in identifying hepatic steatosis in obese children and relation to ultrasonography and metabolic findings. Journal of Pediatric Gastroenterology and Nutrition, 47(4), 493-499.

MRI in identifying hepatic steatosis in obese children and relation to ultrasonography and metabolic findings. / Pozzato, Carlo; Radaelli, Giovanni; Dall'Asta, Chiara; Verduci, Elvira; Villa, Anna; Villa, Chiara; Scaglioni, Silvia; Riva, Enrica; Pontiroli, Antonio E.; Cornalba, Gianpaolo; Giovannini, Marcello.

In: Journal of Pediatric Gastroenterology and Nutrition, Vol. 47, No. 4, 10.2008, p. 493-499.

Research output: Contribution to journalArticle

Pozzato, C, Radaelli, G, Dall'Asta, C, Verduci, E, Villa, A, Villa, C, Scaglioni, S, Riva, E, Pontiroli, AE, Cornalba, G & Giovannini, M 2008, 'MRI in identifying hepatic steatosis in obese children and relation to ultrasonography and metabolic findings', Journal of Pediatric Gastroenterology and Nutrition, vol. 47, no. 4, pp. 493-499.
Pozzato, Carlo ; Radaelli, Giovanni ; Dall'Asta, Chiara ; Verduci, Elvira ; Villa, Anna ; Villa, Chiara ; Scaglioni, Silvia ; Riva, Enrica ; Pontiroli, Antonio E. ; Cornalba, Gianpaolo ; Giovannini, Marcello. / MRI in identifying hepatic steatosis in obese children and relation to ultrasonography and metabolic findings. In: Journal of Pediatric Gastroenterology and Nutrition. 2008 ; Vol. 47, No. 4. pp. 493-499.
@article{c27dfa0d2fb942b5967d77f676beab1a,
title = "MRI in identifying hepatic steatosis in obese children and relation to ultrasonography and metabolic findings",
abstract = "Objectives: The aim of this study was to identify nonalcoholic fatty liver in obese children by magnetic resonance imaging (MRI) and to compare the findings with the data from ultrasonography and from clinical and laboratory testing. Patients and Methods: Sixty obese children, 6 to 14 years old, underwent hepatic MRI and abdominal ultrasonography. Biochemistry determinations included serum aminotransferases, lipid profile, glucose, and insulin. Anthropometry included body mass index, total and trunk fat, and fat-free mass obtained by dual-energy radiographic absorptiometry. Hepatic steatosis, judged as hepatic fat fraction by MRI, was ≥9{\%}. Results: By MRI, 14 (23{\%}) children had hepatic steatosis; of those, 5 had a fat fraction of 9{\%} to 18{\%}, and 9 had a fat fraction >18{\%}. At univariate analysis, fat fraction was positively associated with being male, serum alanine aminotransferase, aspartate aminotransferase, and γ-glutamyltransferase, body mass index z score, insulin, systolic pressure, and total and trunk fat mass. Hepatic steatosis was independently associated with alanine aminotransferase (P18{\%}. All of the children (n=9) with fat fraction ≥18{\%} had increased liver echogenicity, and in 8 of them it was graded 2 or 3, but the MRI fat fraction ranged greatly (28{\%}-45{\%}). Conclusions: In obese children, nonalcoholic hepatic steatosis may be associated with the metabolic syndrome. Ultrasonography may be valuable in identifying high hepatic fat accumulation, but its ability to identify lower fat accumulation in the liver is scanty compared with MRI. JPGN 47:493-499, 2008.",
keywords = "Chemical-shift magnetic resonance imaging, Fatty liver, Obesity, Ultrasound",
author = "Carlo Pozzato and Giovanni Radaelli and Chiara Dall'Asta and Elvira Verduci and Anna Villa and Chiara Villa and Silvia Scaglioni and Enrica Riva and Pontiroli, {Antonio E.} and Gianpaolo Cornalba and Marcello Giovannini",
year = "2008",
month = "10",
language = "English",
volume = "47",
pages = "493--499",
journal = "Journal of Pediatric Gastroenterology and Nutrition",
issn = "0277-2116",
publisher = "Lippincott Williams and Wilkins",
number = "4",

}

TY - JOUR

T1 - MRI in identifying hepatic steatosis in obese children and relation to ultrasonography and metabolic findings

AU - Pozzato, Carlo

AU - Radaelli, Giovanni

AU - Dall'Asta, Chiara

AU - Verduci, Elvira

AU - Villa, Anna

AU - Villa, Chiara

AU - Scaglioni, Silvia

AU - Riva, Enrica

AU - Pontiroli, Antonio E.

AU - Cornalba, Gianpaolo

AU - Giovannini, Marcello

PY - 2008/10

Y1 - 2008/10

N2 - Objectives: The aim of this study was to identify nonalcoholic fatty liver in obese children by magnetic resonance imaging (MRI) and to compare the findings with the data from ultrasonography and from clinical and laboratory testing. Patients and Methods: Sixty obese children, 6 to 14 years old, underwent hepatic MRI and abdominal ultrasonography. Biochemistry determinations included serum aminotransferases, lipid profile, glucose, and insulin. Anthropometry included body mass index, total and trunk fat, and fat-free mass obtained by dual-energy radiographic absorptiometry. Hepatic steatosis, judged as hepatic fat fraction by MRI, was ≥9%. Results: By MRI, 14 (23%) children had hepatic steatosis; of those, 5 had a fat fraction of 9% to 18%, and 9 had a fat fraction >18%. At univariate analysis, fat fraction was positively associated with being male, serum alanine aminotransferase, aspartate aminotransferase, and γ-glutamyltransferase, body mass index z score, insulin, systolic pressure, and total and trunk fat mass. Hepatic steatosis was independently associated with alanine aminotransferase (P18%. All of the children (n=9) with fat fraction ≥18% had increased liver echogenicity, and in 8 of them it was graded 2 or 3, but the MRI fat fraction ranged greatly (28%-45%). Conclusions: In obese children, nonalcoholic hepatic steatosis may be associated with the metabolic syndrome. Ultrasonography may be valuable in identifying high hepatic fat accumulation, but its ability to identify lower fat accumulation in the liver is scanty compared with MRI. JPGN 47:493-499, 2008.

AB - Objectives: The aim of this study was to identify nonalcoholic fatty liver in obese children by magnetic resonance imaging (MRI) and to compare the findings with the data from ultrasonography and from clinical and laboratory testing. Patients and Methods: Sixty obese children, 6 to 14 years old, underwent hepatic MRI and abdominal ultrasonography. Biochemistry determinations included serum aminotransferases, lipid profile, glucose, and insulin. Anthropometry included body mass index, total and trunk fat, and fat-free mass obtained by dual-energy radiographic absorptiometry. Hepatic steatosis, judged as hepatic fat fraction by MRI, was ≥9%. Results: By MRI, 14 (23%) children had hepatic steatosis; of those, 5 had a fat fraction of 9% to 18%, and 9 had a fat fraction >18%. At univariate analysis, fat fraction was positively associated with being male, serum alanine aminotransferase, aspartate aminotransferase, and γ-glutamyltransferase, body mass index z score, insulin, systolic pressure, and total and trunk fat mass. Hepatic steatosis was independently associated with alanine aminotransferase (P18%. All of the children (n=9) with fat fraction ≥18% had increased liver echogenicity, and in 8 of them it was graded 2 or 3, but the MRI fat fraction ranged greatly (28%-45%). Conclusions: In obese children, nonalcoholic hepatic steatosis may be associated with the metabolic syndrome. Ultrasonography may be valuable in identifying high hepatic fat accumulation, but its ability to identify lower fat accumulation in the liver is scanty compared with MRI. JPGN 47:493-499, 2008.

KW - Chemical-shift magnetic resonance imaging

KW - Fatty liver

KW - Obesity

KW - Ultrasound

UR - http://www.scopus.com/inward/record.url?scp=59649111378&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=59649111378&partnerID=8YFLogxK

M3 - Article

C2 - 18852643

AN - SCOPUS:59649111378

VL - 47

SP - 493

EP - 499

JO - Journal of Pediatric Gastroenterology and Nutrition

JF - Journal of Pediatric Gastroenterology and Nutrition

SN - 0277-2116

IS - 4

ER -