MRI in multiple sclerosis during the menstrual cycle: Relationship with sex hormone patterns

Carlo Pozzilli; P. Falaschi; C. Mainero; A. Martocchia; R. D'Urso; A. Proietti; M. Frontoni; S. Bastianello; M. Filippi

MRI in multiple sclerosis during the menstrual cycle: Relationship with sex hormone patterns

Carlo Pozzilli, P. Falaschi, C. Mainero, A. Martocchia, R. D'Urso, A. Proietti, M. Frontoni, S. Bastianello, M. Filippi

Research output: Contribution to journal › Article › peer-review

Abstract

We investigated MRI activity in MS during the menstrual cycle in relation to physiologic sex hormone fluctuations. Eight women with relapsing- remitting MS were submitted to serial brain gadolinium-enhanced MRI examinations over a 3-month period in two alternate follicular and luteal phases of the menstrual cycle. The ratio of progesterone/17-beta-estradiol during the luteal phase was significantly associated with both number (r = 0.6, p = 0.03) and volume (r = 0.7, p = 0.009) of enhancing lesions, providing support for a role of these hormones as immunomodulatory factors in MS.

Original language	English
Pages (from-to)	622-624
Number of pages	3
Journal	Neurology
Volume	53
Issue number	3
Publication status	Published - Aug 11 1999

ASJC Scopus subject areas

Neuroscience(all)

Cite this

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title = "MRI in multiple sclerosis during the menstrual cycle: Relationship with sex hormone patterns",

abstract = "We investigated MRI activity in MS during the menstrual cycle in relation to physiologic sex hormone fluctuations. Eight women with relapsing- remitting MS were submitted to serial brain gadolinium-enhanced MRI examinations over a 3-month period in two alternate follicular and luteal phases of the menstrual cycle. The ratio of progesterone/17-beta-estradiol during the luteal phase was significantly associated with both number (r = 0.6, p = 0.03) and volume (r = 0.7, p = 0.009) of enhancing lesions, providing support for a role of these hormones as immunomodulatory factors in MS.",

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T1 - MRI in multiple sclerosis during the menstrual cycle

T2 - Relationship with sex hormone patterns

AU - Pozzilli, Carlo

AU - Falaschi, P.

AU - Mainero, C.

AU - Martocchia, A.

AU - D'Urso, R.

AU - Proietti, A.

AU - Frontoni, M.

AU - Bastianello, S.

AU - Filippi, M.

PY - 1999/8/11

Y1 - 1999/8/11

N2 - We investigated MRI activity in MS during the menstrual cycle in relation to physiologic sex hormone fluctuations. Eight women with relapsing- remitting MS were submitted to serial brain gadolinium-enhanced MRI examinations over a 3-month period in two alternate follicular and luteal phases of the menstrual cycle. The ratio of progesterone/17-beta-estradiol during the luteal phase was significantly associated with both number (r = 0.6, p = 0.03) and volume (r = 0.7, p = 0.009) of enhancing lesions, providing support for a role of these hormones as immunomodulatory factors in MS.

AB - We investigated MRI activity in MS during the menstrual cycle in relation to physiologic sex hormone fluctuations. Eight women with relapsing- remitting MS were submitted to serial brain gadolinium-enhanced MRI examinations over a 3-month period in two alternate follicular and luteal phases of the menstrual cycle. The ratio of progesterone/17-beta-estradiol during the luteal phase was significantly associated with both number (r = 0.6, p = 0.03) and volume (r = 0.7, p = 0.009) of enhancing lesions, providing support for a role of these hormones as immunomodulatory factors in MS.

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MRI in multiple sclerosis during the menstrual cycle: Relationship with sex hormone patterns

Abstract

ASJC Scopus subject areas

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