MRI in multiple sclerosis during the menstrual cycle: Relationship with sex hormone patterns

Carlo Pozzilli, P. Falaschi, C. Mainero, A. Martocchia, R. D'Urso, A. Proietti, M. Frontoni, S. Bastianello, M. Filippi

Research output: Contribution to journalArticlepeer-review

Abstract

We investigated MRI activity in MS during the menstrual cycle in relation to physiologic sex hormone fluctuations. Eight women with relapsing- remitting MS were submitted to serial brain gadolinium-enhanced MRI examinations over a 3-month period in two alternate follicular and luteal phases of the menstrual cycle. The ratio of progesterone/17-beta-estradiol during the luteal phase was significantly associated with both number (r = 0.6, p = 0.03) and volume (r = 0.7, p = 0.009) of enhancing lesions, providing support for a role of these hormones as immunomodulatory factors in MS.

Original languageEnglish
Pages (from-to)622-624
Number of pages3
JournalNeurology
Volume53
Issue number3
Publication statusPublished - Aug 11 1999

ASJC Scopus subject areas

  • Neuroscience(all)

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