MRI investigation of temporal lobe structures in bipolar patients

Paolo Brambilla, Keith Harenski, Mark Nicoletti, Roberto B. Sassi, Alan G. Mallinger, Ellen Frank, David J. Kupfer, Matcheri S. Keshavan, Jair C. Soares

Research output: Contribution to journalArticle

Abstract

Previous anatomical MRI studies have suggested abnormalities in amygdala volumes in bipolar disorder, whereas hippocampus, temporal lobe (TL), and superior temporal gyri (STG) measures have been reported to be normal. This study further investigated the existence of anatomical abnormalities in these brain structures in bipolar subjects, to attempt to replicate previously reported findings. Twenty-four DSM-IV bipolar patients (mean age±S.D.=35±10 years) and 36 healthy controls (mean age±S.D.=37±10 years) were studied. 3D SPGR images were obtained with a 1.5T-GE Signa magnet (TR=25 ms, TE=5 ms, FOV=24 cm, slice-thickness=1.5 mm, matrix-size=256×192). Volumetric measurements of TL, hippocampus, amygdala, and STG were performed blindly, with a semi-automated software. Bipolar patients had significantly larger left amygdala volumes compared with controls (mean volumes±S.D.=2.57±0.69 vs. 2.17±0.58 ml, respectively; ANCOVA, age, gender, ICV as covariates; F=4.42, df=1/55, P=0.04). The volumes of the other temporal lobe structures did not differ significantly between the two groups (ANCOVA, age, gender, and ICV as covariates, P>0.05). Our findings of enlarged left amygdala in bipolar patients are in agreement with prior MRI studies, suggesting that abnormalities in this brain structure may be implicated in pathophysiology of the illness. Longitudinal studies in high-risk offspring and first-episode patients will be needed to examine whether such abnormalities precede the appearance of symptoms, or whether they may appear subsequently as a result of illness course.

Original languageEnglish
Pages (from-to)287-295
Number of pages9
JournalJournal of Psychiatric Research
Volume37
Issue number4
DOIs
Publication statusPublished - Jul 2003

Keywords

  • Amygdala
  • Bipolar disorder
  • Hippocampus
  • Magnetic resonance imaging
  • Superior temporal gyrus
  • Temporal lobes

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry
  • Psychology(all)

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  • Cite this

    Brambilla, P., Harenski, K., Nicoletti, M., Sassi, R. B., Mallinger, A. G., Frank, E., Kupfer, D. J., Keshavan, M. S., & Soares, J. C. (2003). MRI investigation of temporal lobe structures in bipolar patients. Journal of Psychiatric Research, 37(4), 287-295. https://doi.org/10.1016/S0022-3956(03)00024-4