MRI of the wrist in juvenile idiopathic arthritis: Erosions or normal variants? A prospective case-control study

Lil Sofie Ording Muller, Peter Boavida, Derk Avenarius, Beatrice Damasio, Odd Petter Eldevik, Clara Malattia, Karen Lambot-Juhan, Laura Tanturri, Catherine M. Owens, Karen Rosendahl

Research output: Contribution to journalArticle

Abstract

Background: Bony depressions at the wrist resembling erosions are frequently seen on MRI in healthy children. The accuracy of MRI in detecting early bony destruction is therefore questionable. We compared findings on MRI of the wrist in healthy children and those with juvenile idiopathic arthritis (JIA) to investigate markers for true disease. Materials and methods: We compared the number and localisation of bony depressions at the wrist in 85 healthy children and 68 children with JIA, ages 5-15 years. The size of the wrist was assessed from a radiograph of the wrist performed on the same day as the MRI. Results: No significant difference in the number of bony depressions in the carpal bones was seen between healthy children and children with JIA at any age. Depressions are found in similar locations in the two groups, except for a few sites, where bony depressions were seen exclusively in the JIA group, particularly at the CMC joints. The wrist was significantly smaller in children with JIA (P <0.001). Conclusions: Using adult scoring systems and standard MR sequences in the assessment of bone destruction in children may lead to overstaging or understaging of disease. At present, standard MRI sequences cannot easily be used for assessment of early signs of erosions in children.

Original languageEnglish
Pages (from-to)785-795
Number of pages11
JournalPediatric Radiology
Volume43
Issue number7
DOIs
Publication statusPublished - Jul 2013

Fingerprint

Juvenile Arthritis
Wrist
Case-Control Studies
Carpal Bones
Joints
Bone and Bones

Keywords

  • Children
  • Erosions
  • JIA
  • Juvenile idiopathic arthritis
  • MRI
  • Normal
  • Wrist

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Pediatrics, Perinatology, and Child Health

Cite this

MRI of the wrist in juvenile idiopathic arthritis : Erosions or normal variants? A prospective case-control study. / Ording Muller, Lil Sofie; Boavida, Peter; Avenarius, Derk; Damasio, Beatrice; Eldevik, Odd Petter; Malattia, Clara; Lambot-Juhan, Karen; Tanturri, Laura; Owens, Catherine M.; Rosendahl, Karen.

In: Pediatric Radiology, Vol. 43, No. 7, 07.2013, p. 785-795.

Research output: Contribution to journalArticle

Ording Muller, LS, Boavida, P, Avenarius, D, Damasio, B, Eldevik, OP, Malattia, C, Lambot-Juhan, K, Tanturri, L, Owens, CM & Rosendahl, K 2013, 'MRI of the wrist in juvenile idiopathic arthritis: Erosions or normal variants? A prospective case-control study', Pediatric Radiology, vol. 43, no. 7, pp. 785-795. https://doi.org/10.1007/s00247-012-2575-z
Ording Muller, Lil Sofie ; Boavida, Peter ; Avenarius, Derk ; Damasio, Beatrice ; Eldevik, Odd Petter ; Malattia, Clara ; Lambot-Juhan, Karen ; Tanturri, Laura ; Owens, Catherine M. ; Rosendahl, Karen. / MRI of the wrist in juvenile idiopathic arthritis : Erosions or normal variants? A prospective case-control study. In: Pediatric Radiology. 2013 ; Vol. 43, No. 7. pp. 785-795.
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