MRI predictors of long-term evolution in amyotrophic lateral sclerosis

Federica Agosta, Elisabetta Pagani, Melissa Petrolini, Maria P. Sormani, Domenico Caputo, Michele Perini, Alessandro Prelle, Fabrizio Salvi, Massimo Filippi

Research output: Contribution to journalArticle

36 Citations (Scopus)

Abstract

We investigated whether conventional and diffusion tensor (DT) magnetic resonance imaging (MRI) features of the corticospinal tract (CST) contribute to the prediction of the long-term clinical evolution in patients with amyotrophic lateral sclerosis (ALS). Brain conventional and DT MRI were obtained from 18 healthy subjects and 24 patients with sporadic ALS. Mean diffusivity (MD) and fractional anisotropy (FA) of the CST were obtained. Patients were scanned at baseline, then entered a longitudinal clinical follow-up. The ALS Functional Rating scale (ALSFRS) progression rate during follow-up was estimated. Patients were followed up prospectively for a median period of 3.4 years. Two patients were lost at follow-up and eight died during the observation period. The mean ALSFRS progression rate was 0.7/month (range = 0.0-2.0/month). At baseline, ALS patients showed significantly increased MD and decreased FA of the CST compared with controls. CST FA was associated with ALSFRS progression rate. ALSFRS deterioration rate and CST FA were independent predictors of survival in ALS patients. Survival at year 3 was 42% in patients with CST FA ≤ 0.56 compared with 90% in patients with CST FA > 0.56. This study shows that more severe CST DT MRI abnormalities predict a poorer long-term clinical outcome in ALS patients. DT MRI of the brain has the potential to offer in vivo markers of disease severity.

Original languageEnglish
Pages (from-to)1490-1496
Number of pages7
JournalEuropean Journal of Neuroscience
Volume32
Issue number9
DOIs
Publication statusPublished - Nov 2010

Fingerprint

Amyotrophic Lateral Sclerosis
Pyramidal Tracts
Magnetic Resonance Imaging
Anisotropy
Diffusion Magnetic Resonance Imaging
Survival
Brain
Healthy Volunteers
Observation

Keywords

  • Diffusion tensor magnetic resonance imaging
  • Disability progression
  • Human prognosis
  • Survival

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

MRI predictors of long-term evolution in amyotrophic lateral sclerosis. / Agosta, Federica; Pagani, Elisabetta; Petrolini, Melissa; Sormani, Maria P.; Caputo, Domenico; Perini, Michele; Prelle, Alessandro; Salvi, Fabrizio; Filippi, Massimo.

In: European Journal of Neuroscience, Vol. 32, No. 9, 11.2010, p. 1490-1496.

Research output: Contribution to journalArticle

Agosta, Federica ; Pagani, Elisabetta ; Petrolini, Melissa ; Sormani, Maria P. ; Caputo, Domenico ; Perini, Michele ; Prelle, Alessandro ; Salvi, Fabrizio ; Filippi, Massimo. / MRI predictors of long-term evolution in amyotrophic lateral sclerosis. In: European Journal of Neuroscience. 2010 ; Vol. 32, No. 9. pp. 1490-1496.
@article{1dd102d8d5f5489d95e957dd902d1149,
title = "MRI predictors of long-term evolution in amyotrophic lateral sclerosis",
abstract = "We investigated whether conventional and diffusion tensor (DT) magnetic resonance imaging (MRI) features of the corticospinal tract (CST) contribute to the prediction of the long-term clinical evolution in patients with amyotrophic lateral sclerosis (ALS). Brain conventional and DT MRI were obtained from 18 healthy subjects and 24 patients with sporadic ALS. Mean diffusivity (MD) and fractional anisotropy (FA) of the CST were obtained. Patients were scanned at baseline, then entered a longitudinal clinical follow-up. The ALS Functional Rating scale (ALSFRS) progression rate during follow-up was estimated. Patients were followed up prospectively for a median period of 3.4 years. Two patients were lost at follow-up and eight died during the observation period. The mean ALSFRS progression rate was 0.7/month (range = 0.0-2.0/month). At baseline, ALS patients showed significantly increased MD and decreased FA of the CST compared with controls. CST FA was associated with ALSFRS progression rate. ALSFRS deterioration rate and CST FA were independent predictors of survival in ALS patients. Survival at year 3 was 42{\%} in patients with CST FA ≤ 0.56 compared with 90{\%} in patients with CST FA > 0.56. This study shows that more severe CST DT MRI abnormalities predict a poorer long-term clinical outcome in ALS patients. DT MRI of the brain has the potential to offer in vivo markers of disease severity.",
keywords = "Diffusion tensor magnetic resonance imaging, Disability progression, Human prognosis, Survival",
author = "Federica Agosta and Elisabetta Pagani and Melissa Petrolini and Sormani, {Maria P.} and Domenico Caputo and Michele Perini and Alessandro Prelle and Fabrizio Salvi and Massimo Filippi",
year = "2010",
month = "11",
doi = "10.1111/j.1460-9568.2010.07445.x",
language = "English",
volume = "32",
pages = "1490--1496",
journal = "European Journal of Neuroscience",
issn = "0953-816X",
publisher = "Wiley-Blackwell",
number = "9",

}

TY - JOUR

T1 - MRI predictors of long-term evolution in amyotrophic lateral sclerosis

AU - Agosta, Federica

AU - Pagani, Elisabetta

AU - Petrolini, Melissa

AU - Sormani, Maria P.

AU - Caputo, Domenico

AU - Perini, Michele

AU - Prelle, Alessandro

AU - Salvi, Fabrizio

AU - Filippi, Massimo

PY - 2010/11

Y1 - 2010/11

N2 - We investigated whether conventional and diffusion tensor (DT) magnetic resonance imaging (MRI) features of the corticospinal tract (CST) contribute to the prediction of the long-term clinical evolution in patients with amyotrophic lateral sclerosis (ALS). Brain conventional and DT MRI were obtained from 18 healthy subjects and 24 patients with sporadic ALS. Mean diffusivity (MD) and fractional anisotropy (FA) of the CST were obtained. Patients were scanned at baseline, then entered a longitudinal clinical follow-up. The ALS Functional Rating scale (ALSFRS) progression rate during follow-up was estimated. Patients were followed up prospectively for a median period of 3.4 years. Two patients were lost at follow-up and eight died during the observation period. The mean ALSFRS progression rate was 0.7/month (range = 0.0-2.0/month). At baseline, ALS patients showed significantly increased MD and decreased FA of the CST compared with controls. CST FA was associated with ALSFRS progression rate. ALSFRS deterioration rate and CST FA were independent predictors of survival in ALS patients. Survival at year 3 was 42% in patients with CST FA ≤ 0.56 compared with 90% in patients with CST FA > 0.56. This study shows that more severe CST DT MRI abnormalities predict a poorer long-term clinical outcome in ALS patients. DT MRI of the brain has the potential to offer in vivo markers of disease severity.

AB - We investigated whether conventional and diffusion tensor (DT) magnetic resonance imaging (MRI) features of the corticospinal tract (CST) contribute to the prediction of the long-term clinical evolution in patients with amyotrophic lateral sclerosis (ALS). Brain conventional and DT MRI were obtained from 18 healthy subjects and 24 patients with sporadic ALS. Mean diffusivity (MD) and fractional anisotropy (FA) of the CST were obtained. Patients were scanned at baseline, then entered a longitudinal clinical follow-up. The ALS Functional Rating scale (ALSFRS) progression rate during follow-up was estimated. Patients were followed up prospectively for a median period of 3.4 years. Two patients were lost at follow-up and eight died during the observation period. The mean ALSFRS progression rate was 0.7/month (range = 0.0-2.0/month). At baseline, ALS patients showed significantly increased MD and decreased FA of the CST compared with controls. CST FA was associated with ALSFRS progression rate. ALSFRS deterioration rate and CST FA were independent predictors of survival in ALS patients. Survival at year 3 was 42% in patients with CST FA ≤ 0.56 compared with 90% in patients with CST FA > 0.56. This study shows that more severe CST DT MRI abnormalities predict a poorer long-term clinical outcome in ALS patients. DT MRI of the brain has the potential to offer in vivo markers of disease severity.

KW - Diffusion tensor magnetic resonance imaging

KW - Disability progression

KW - Human prognosis

KW - Survival

UR - http://www.scopus.com/inward/record.url?scp=78149263085&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=78149263085&partnerID=8YFLogxK

U2 - 10.1111/j.1460-9568.2010.07445.x

DO - 10.1111/j.1460-9568.2010.07445.x

M3 - Article

VL - 32

SP - 1490

EP - 1496

JO - European Journal of Neuroscience

JF - European Journal of Neuroscience

SN - 0953-816X

IS - 9

ER -