TY - JOUR
T1 - MRI quantification of gray and white matter damage in patients with early-onset multiple sclerosis
AU - Tortorella, P.
AU - Rocca, M. A.
AU - Mezzapesa, D. M.
AU - Ghezzi, A.
AU - Lamantia, L.
AU - Comi, G.
AU - Filippi, M.
PY - 2006/7
Y1 - 2006/7
N2 - Background and objective: Contrary to what happens in adult-onset multiple sclerosis (MS), in a previous preliminary magnetic resonance imaging (MRI) study we showed only subtle normal-appearing brain tissue changes in patients with earlyonset MS. Our objective was to evaluate the presence and extent of tissue damage in the brain normalappearing white matter (NAWM) and gray matter (GM) from a larger population of patients with earlyonset MS. Methods: Using diffusion tensor (DT) and magnetization transfer (MT) MRI, we obtained DT and MT ratio (MTR) maps of the NAWM and GM from 23 patients with early-onset MS and 16 sex- and age-matched healthy volunteers. Results: Compared with healthy volunteers, patients with early-onset MS had significantly increased average MD (p = 0.02) and FA peak height (p = 0.007) and decreased average FA (p
AB - Background and objective: Contrary to what happens in adult-onset multiple sclerosis (MS), in a previous preliminary magnetic resonance imaging (MRI) study we showed only subtle normal-appearing brain tissue changes in patients with earlyonset MS. Our objective was to evaluate the presence and extent of tissue damage in the brain normalappearing white matter (NAWM) and gray matter (GM) from a larger population of patients with earlyonset MS. Methods: Using diffusion tensor (DT) and magnetization transfer (MT) MRI, we obtained DT and MT ratio (MTR) maps of the NAWM and GM from 23 patients with early-onset MS and 16 sex- and age-matched healthy volunteers. Results: Compared with healthy volunteers, patients with early-onset MS had significantly increased average MD (p = 0.02) and FA peak height (p = 0.007) and decreased average FA (p
KW - Diffusion tensor MRI
KW - Magnetic resonance imaging
KW - Magnetization transfer MRI
KW - Multiple sclerosis
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U2 - 10.1007/s00415-006-0129-8
DO - 10.1007/s00415-006-0129-8
M3 - Article
C2 - 16511645
AN - SCOPUS:33746257564
VL - 253
SP - 903
EP - 907
JO - Journal of Neurology
JF - Journal of Neurology
SN - 0340-5354
IS - 7
ER -