MRI quantification of gray and white matter damage in patients with early-onset multiple sclerosis

P. Tortorella, M. A. Rocca, D. M. Mezzapesa, A. Ghezzi, L. Lamantia, G. Comi, M. Filippi

Research output: Contribution to journalArticlepeer-review

Abstract

Background and objective: Contrary to what happens in adult-onset multiple sclerosis (MS), in a previous preliminary magnetic resonance imaging (MRI) study we showed only subtle normal-appearing brain tissue changes in patients with earlyonset MS. Our objective was to evaluate the presence and extent of tissue damage in the brain normalappearing white matter (NAWM) and gray matter (GM) from a larger population of patients with earlyonset MS. Methods: Using diffusion tensor (DT) and magnetization transfer (MT) MRI, we obtained DT and MT ratio (MTR) maps of the NAWM and GM from 23 patients with early-onset MS and 16 sex- and age-matched healthy volunteers. Results: Compared with healthy volunteers, patients with early-onset MS had significantly increased average MD (p = 0.02) and FA peak height (p = 0.007) and decreased average FA (p

Original languageEnglish
Pages (from-to)903-907
Number of pages5
JournalJournal of Neurology
Volume253
Issue number7
DOIs
Publication statusPublished - Jul 2006

Keywords

  • Diffusion tensor MRI
  • Magnetic resonance imaging
  • Magnetization transfer MRI
  • Multiple sclerosis

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology

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