MRI quantification of gray and white matter damage in patients with early-onset multiple sclerosis

P. Tortorella; M. A. Rocca; D. M. Mezzapesa; A. Ghezzi; L. Lamantia; G. Comi; M. Filippi

doi:10.1007/s00415-006-0129-8

MRI quantification of gray and white matter damage in patients with early-onset multiple sclerosis

P. Tortorella, M. A. Rocca, D. M. Mezzapesa, A. Ghezzi, L. Lamantia, G. Comi, M. Filippi

IRCCS Ospedale San Raffaele

Research output: Contribution to journal › Article › peer-review

Abstract

Background and objective: Contrary to what happens in adult-onset multiple sclerosis (MS), in a previous preliminary magnetic resonance imaging (MRI) study we showed only subtle normal-appearing brain tissue changes in patients with earlyonset MS. Our objective was to evaluate the presence and extent of tissue damage in the brain normalappearing white matter (NAWM) and gray matter (GM) from a larger population of patients with earlyonset MS. Methods: Using diffusion tensor (DT) and magnetization transfer (MT) MRI, we obtained DT and MT ratio (MTR) maps of the NAWM and GM from 23 patients with early-onset MS and 16 sex- and age-matched healthy volunteers. Results: Compared with healthy volunteers, patients with early-onset MS had significantly increased average MD (p = 0.02) and FA peak height (p = 0.007) and decreased average FA (p

Original language	English
Pages (from-to)	903-907
Number of pages	5
Journal	Journal of Neurology
Volume	253
Issue number	7
DOIs	https://doi.org/10.1007/s00415-006-0129-8
Publication status	Published - Jul 2006

Keywords

Diffusion tensor MRI
Magnetic resonance imaging
Magnetization transfer MRI
Multiple sclerosis

ASJC Scopus subject areas

Clinical Neurology
Neurology

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10.1007/s00415-006-0129-8

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title = "MRI quantification of gray and white matter damage in patients with early-onset multiple sclerosis",

abstract = "Background and objective: Contrary to what happens in adult-onset multiple sclerosis (MS), in a previous preliminary magnetic resonance imaging (MRI) study we showed only subtle normal-appearing brain tissue changes in patients with earlyonset MS. Our objective was to evaluate the presence and extent of tissue damage in the brain normalappearing white matter (NAWM) and gray matter (GM) from a larger population of patients with earlyonset MS. Methods: Using diffusion tensor (DT) and magnetization transfer (MT) MRI, we obtained DT and MT ratio (MTR) maps of the NAWM and GM from 23 patients with early-onset MS and 16 sex- and age-matched healthy volunteers. Results: Compared with healthy volunteers, patients with early-onset MS had significantly increased average MD (p = 0.02) and FA peak height (p = 0.007) and decreased average FA (p ",

keywords = "Diffusion tensor MRI, Magnetic resonance imaging, Magnetization transfer MRI, Multiple sclerosis",

author = "P. Tortorella and Rocca, {M. A.} and Mezzapesa, {D. M.} and A. Ghezzi and L. Lamantia and G. Comi and M. Filippi",

year = "2006",

month = jul,

doi = "10.1007/s00415-006-0129-8",

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T1 - MRI quantification of gray and white matter damage in patients with early-onset multiple sclerosis

AU - Tortorella, P.

AU - Rocca, M. A.

AU - Mezzapesa, D. M.

AU - Ghezzi, A.

AU - Lamantia, L.

AU - Comi, G.

AU - Filippi, M.

PY - 2006/7

Y1 - 2006/7

N2 - Background and objective: Contrary to what happens in adult-onset multiple sclerosis (MS), in a previous preliminary magnetic resonance imaging (MRI) study we showed only subtle normal-appearing brain tissue changes in patients with earlyonset MS. Our objective was to evaluate the presence and extent of tissue damage in the brain normalappearing white matter (NAWM) and gray matter (GM) from a larger population of patients with earlyonset MS. Methods: Using diffusion tensor (DT) and magnetization transfer (MT) MRI, we obtained DT and MT ratio (MTR) maps of the NAWM and GM from 23 patients with early-onset MS and 16 sex- and age-matched healthy volunteers. Results: Compared with healthy volunteers, patients with early-onset MS had significantly increased average MD (p = 0.02) and FA peak height (p = 0.007) and decreased average FA (p

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KW - Diffusion tensor MRI

KW - Magnetic resonance imaging

KW - Magnetization transfer MRI

KW - Multiple sclerosis

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