MRI substrates of sustained attention system and cognitive impairment in pediatric MS patients

Ermelinda De Meo, Lucia Moiola, Angelo Ghezzi, Pierangelo Veggiotti, Ruggero Capra, Maria Pia Amato, Elisabetta Pagani, Agnese Fiorino, Lorena Pippolo, Maria C Pera, Giancarlo Comi, Andrea Falini, Massimo Filippi, Maria A Rocca

Research output: Contribution to journalArticlepeer-review


OBJECTIVE: To explore the structural and functional integrity of the sustained attention system in patients with pediatric multiple sclerosis (MS) and its effect on cognitive impairment.

METHODS: We enrolled 57 patients with pediatric MS and 14 age- and sex-matched healthy controls (HCs). Patients with >3 abnormal tests at neuropsychological evaluation were classified as cognitively impaired (CI). Sustained attention system activity was studied with fMRI during the Conners Continuous Performance Test (CCPT). Structural integrity of attention network connections was quantified with diffusion tensor (DT) MRI.

RESULTS: Within-group analysis showed similar patterns of recruitment of the attention network in HCs and patients with pediatric MS. Diffuse network DT MRI structural abnormalities were found in patients with MS. During CCPT, with increasing task demand, patients with pediatric MS showed increased activation of the left thalamus, anterior insula, and anterior cingulate cortex (ACC) and decreased recruitment of the right precuneus compared to HCs. Thirteen patients (23%) were classified as CI. Compared to cognitively preserved patients, CI patients with pediatric MS had decreased recruitment of several areas located mainly in parietal and occipital lobes and cerebellum and increased deactivation of the ACC, combined with more severe structural damage of white matter tracts connecting these regions.

CONCLUSIONS: Our results suggest that the age-expected level of sustained attention system functional competence is achieved in patients with pediatric MS. Inefficient regulation of the functional interaction between different areas of this system, due to abnormal white matter integrity, may result in global cognitive impairment in these patients.

Original languageEnglish
Pages (from-to)1265-1273
Number of pages9
Issue number12
Publication statusPublished - Sep 19 2017


  • Adolescent
  • Attention
  • Cerebellum
  • Cerebral Cortex
  • Child
  • Cognitive Dysfunction
  • Diffusion Tensor Imaging
  • Female
  • Gyrus Cinguli
  • Humans
  • Magnetic Resonance Imaging
  • Male
  • Multiple Sclerosis
  • Psychomotor Performance
  • Thalamus
  • White Matter
  • Journal Article


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