MRI T2 lesion burden in multiple sclerosis: A plateauing relationship with clinical disability

D. K B Li, U. Held, J. Petkau, M. Daumer, F. Barkhof, F. Fazekas, J. A. Frank, L. Kappos, D. H. Miller, J. H. Simon, J. S. Wolinsky, M. Filippi

Research output: Contribution to journalArticlepeer-review

Abstract

Background: Previous studies have shown only modest correlation between multiple sclerosis (MS) lesions on MRI and clinical disability. Objective: To investigate the relationship between proton density/T2-weighted (T2) burden of disease (BOD) quantitatively measured on MRI scans and clinical determinants including disability. Methods: Using the Sylvia Lawry Centre for Multiple Sclerosis Research (SLCMSR) database, the authors studied baseline T2 BOD data from a pooled subsample of 1,312 placebo MS patients from 11 randomized controlled trials. Univariate comparisons guided development of multiple regression models incorporating the most important clinical predictors. Results: Significant, although weak to moderate, correlations were found between T2 BOD and age at disease onset, disease duration, disease course, disability (as measured by the Expanded Disability Status Scale [EDSS]), relapse rate, certain presenting symptoms, and gadolinium enhancement. An unexpected but key finding that persisted in the multiple regression analyses was a plateauing relationship between T2 BOD and disability for EDSS values above 4.5. Conclusions: This study confirmed the limited correlation between clinical manifestations and T2 burden of disease (BOD) but revealed an important plateauing relationship between T2 BOD and disability.

Original languageEnglish
Pages (from-to)1384-1389
Number of pages6
JournalNeurology
Volume66
Issue number9
DOIs
Publication statusPublished - May 2006

ASJC Scopus subject areas

  • Neuroscience(all)

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