MRI tractography of corticospinal tract and arcuate fasciculus in high-grade gliomas performed by constrained spherical deconvolution: Qualitative and quantitative analysis

E. Mormina, M. Longo, A. Arrigo, C. Alafaci, F. Tomasello, A. Calamuneri, S. Marino, M. Gaeta, S. L. Vinci, F. Granata

Research output: Contribution to journalArticle

Abstract

BACKGROUND AND PURPOSE: MR imaging tractography is increasingly used to perform noninvasive presurgical planning for brain gliomas. Recently, constrained spherical deconvolution tractography was shown to overcome several limitations of commonly used DTI tractography. The purpose of our study was to evaluate WM tract alterations of both the corticospinal tract and arcuate fasciculus in patients with high-grade gliomas, through qualitative and quantitative analysis of probabilistic constrained spherical deconvolution tractography, to perform reliable presurgical planning. MATERIALS AND METHODS: Twenty patients with frontoparietal high-grade gliomas were recruited and evaluated by using a 3T MR imaging scanner with both morphologic and diffusion sequences (60 diffusion directions). We performed probabilistic constrained spherical deconvolution tractography and tract quantification following diffusion tensor parameters: fractional anisotropy; mean diffusivity; linear, planar, and spherical coefficients. RESULTS: In all patients, we obtained tractographic reconstructions of the medial and lateral portions of the corticospinal tract and arcuate fasciculus, both on the glioma-affected and nonaffected sides of the brain. The affected lateral corticospinal tract and the arcuate fasciculus showed decreased fractional anisotropy (z-2.51, n-20, P <.006; z-2.52, n-20, P <.006) and linear coefficient (z 2.51, n-20, P

Original languageEnglish
Pages (from-to)1853-1858
Number of pages6
JournalAmerican Journal of Neuroradiology
Volume36
Issue number10
DOIs
Publication statusPublished - Oct 1 2015

Keywords

  • AF-arcuate fasciculus
  • Cl-linear coefficient
  • Cp-planar coefficient
  • Cs-spherical coefficient
  • CSD-constrained spherical deconvolution
  • CST-corticospinal tract
  • FA-fractional anisotropy
  • HGG-high-grade glioma
  • MD-mean diffusivity

ASJC Scopus subject areas

  • Clinical Neurology
  • Radiology Nuclear Medicine and imaging

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