mRNA distribution in adult human brain of GRIN2B, a N-methyl-D-aspartate (NMDA) receptor subunit

A. M. Schito, A. Pizzuti, E. Di Maria, A. Schenone, A. Ratti, R. Defferrari, E. Bellone, G. L. Mancardi, F. Ajmar, P. Mandich

Research output: Contribution to journalArticle

Abstract

The expression of the N-methyl-D-aspartate (NMDA) receptor subunit NR2B/ε2 (GRIN2B) in the human adult brain was assayed by in situ hybridisation, by using a specific cRNA probe. The full length GRIN2B cDNA was cloned and sequenced. It showed a 90% nucleotide conservation when compared to the rodent homologue. GRIN2B gene is expressed at high levels in the fronto-parieto-temporal cortex and hippocampus pyramidal cells and, at a lower extent, in the basal ganglia (amygdala and striatum). The cerebellar granule cells does not show any mRNA expression. The non-ubiquitous anatomical distribution of the GRIN2B mRNA in the central nervous system suggests that the gene could be involved in specific functions pertaining to the expressing cell groups.

Original languageEnglish
Pages (from-to)49-53
Number of pages5
JournalNeuroscience Letters
Volume239
Issue number1
DOIs
Publication statusPublished - Dec 12 1997

Keywords

  • Glutamate
  • GRIN2B
  • In situ hybridisation
  • N-Methyl-D-aspartate

ASJC Scopus subject areas

  • Neuroscience(all)

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    Schito, A. M., Pizzuti, A., Di Maria, E., Schenone, A., Ratti, A., Defferrari, R., Bellone, E., Mancardi, G. L., Ajmar, F., & Mandich, P. (1997). mRNA distribution in adult human brain of GRIN2B, a N-methyl-D-aspartate (NMDA) receptor subunit. Neuroscience Letters, 239(1), 49-53. https://doi.org/10.1016/S0304-3940(97)00853-7