mRNA distribution in adult human brain of GRIN2B, a N-methyl-D-aspartate (NMDA) receptor subunit

A. M. Schito; A. Pizzuti; E. Di Maria; A. Schenone; A. Ratti; R. Defferrari; E. Bellone; G. L. Mancardi; F. Ajmar; P. Mandich

doi:10.1016/S0304-3940(97)00853-7

mRNA distribution in adult human brain of GRIN2B, a N-methyl-D-aspartate (NMDA) receptor subunit

A. M. Schito, A. Pizzuti, E. Di Maria, A. Schenone, A. Ratti, R. Defferrari, E. Bellone, G. L. Mancardi, F. Ajmar, P. Mandich

Research output: Contribution to journal › Article

Abstract

The expression of the N-methyl-D-aspartate (NMDA) receptor subunit NR2B/ε2 (GRIN2B) in the human adult brain was assayed by in situ hybridisation, by using a specific cRNA probe. The full length GRIN2B cDNA was cloned and sequenced. It showed a 90% nucleotide conservation when compared to the rodent homologue. GRIN2B gene is expressed at high levels in the fronto-parieto-temporal cortex and hippocampus pyramidal cells and, at a lower extent, in the basal ganglia (amygdala and striatum). The cerebellar granule cells does not show any mRNA expression. The non-ubiquitous anatomical distribution of the GRIN2B mRNA in the central nervous system suggests that the gene could be involved in specific functions pertaining to the expressing cell groups.

Original language	English
Pages (from-to)	49-53
Number of pages	5
Journal	Neuroscience Letters
Volume	239
Issue number	1
DOIs	https://doi.org/10.1016/S0304-3940(97)00853-7
Publication status	Published - Dec 12 1997

Keywords

Glutamate
GRIN2B
In situ hybridisation
N-Methyl-D-aspartate

ASJC Scopus subject areas

Neuroscience(all)

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10.1016/S0304-3940(97)00853-7

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Schito, A. M., Pizzuti, A., Di Maria, E., Schenone, A., Ratti, A., Defferrari, R., Bellone, E., Mancardi, G. L., Ajmar, F., & Mandich, P. (1997). mRNA distribution in adult human brain of GRIN2B, a N-methyl-D-aspartate (NMDA) receptor subunit. Neuroscience Letters, 239(1), 49-53. https://doi.org/10.1016/S0304-3940(97)00853-7

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abstract = "The expression of the N-methyl-D-aspartate (NMDA) receptor subunit NR2B/ε2 (GRIN2B) in the human adult brain was assayed by in situ hybridisation, by using a specific cRNA probe. The full length GRIN2B cDNA was cloned and sequenced. It showed a 90% nucleotide conservation when compared to the rodent homologue. GRIN2B gene is expressed at high levels in the fronto-parieto-temporal cortex and hippocampus pyramidal cells and, at a lower extent, in the basal ganglia (amygdala and striatum). The cerebellar granule cells does not show any mRNA expression. The non-ubiquitous anatomical distribution of the GRIN2B mRNA in the central nervous system suggests that the gene could be involved in specific functions pertaining to the expressing cell groups.",

keywords = "Glutamate, GRIN2B, In situ hybridisation, N-Methyl-D-aspartate",

author = "Schito, {A. M.} and A. Pizzuti and {Di Maria}, E. and A. Schenone and A. Ratti and R. Defferrari and E. Bellone and Mancardi, {G. L.} and F. Ajmar and P. Mandich",

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AU - Schito, A. M.

AU - Pizzuti, A.

AU - Di Maria, E.

AU - Schenone, A.

AU - Ratti, A.

AU - Defferrari, R.

AU - Bellone, E.

AU - Mancardi, G. L.

AU - Ajmar, F.

AU - Mandich, P.

PY - 1997/12/12

Y1 - 1997/12/12

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AB - The expression of the N-methyl-D-aspartate (NMDA) receptor subunit NR2B/ε2 (GRIN2B) in the human adult brain was assayed by in situ hybridisation, by using a specific cRNA probe. The full length GRIN2B cDNA was cloned and sequenced. It showed a 90% nucleotide conservation when compared to the rodent homologue. GRIN2B gene is expressed at high levels in the fronto-parieto-temporal cortex and hippocampus pyramidal cells and, at a lower extent, in the basal ganglia (amygdala and striatum). The cerebellar granule cells does not show any mRNA expression. The non-ubiquitous anatomical distribution of the GRIN2B mRNA in the central nervous system suggests that the gene could be involved in specific functions pertaining to the expressing cell groups.

KW - Glutamate

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KW - In situ hybridisation

KW - N-Methyl-D-aspartate

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