Abstract
The expression of the N-methyl-D-aspartate (NMDA) receptor subunit NR2B/ε2 (GRIN2B) in the human adult brain was assayed by in situ hybridisation, by using a specific cRNA probe. The full length GRIN2B cDNA was cloned and sequenced. It showed a 90% nucleotide conservation when compared to the rodent homologue. GRIN2B gene is expressed at high levels in the fronto-parieto-temporal cortex and hippocampus pyramidal cells and, at a lower extent, in the basal ganglia (amygdala and striatum). The cerebellar granule cells does not show any mRNA expression. The non-ubiquitous anatomical distribution of the GRIN2B mRNA in the central nervous system suggests that the gene could be involved in specific functions pertaining to the expressing cell groups.
Original language | English |
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Pages (from-to) | 49-53 |
Number of pages | 5 |
Journal | Neuroscience Letters |
Volume | 239 |
Issue number | 1 |
DOIs | |
Publication status | Published - Dec 12 1997 |
Keywords
- Glutamate
- GRIN2B
- In situ hybridisation
- N-Methyl-D-aspartate
ASJC Scopus subject areas
- Neuroscience(all)