TY - JOUR
T1 - MRSA nasal colonization in children
T2 - Prevalence meta-analysis, review of risk factors and molecular genetics
AU - Gesualdo, Francesco
AU - Bongiorno, Dafne
AU - Rizzo, Caterina
AU - Bella, Antonino
AU - Menichella, Donato
AU - Stefani, Stefania
AU - Tozzi, Alberto E.
PY - 2013/1/21
Y1 - 2013/1/21
N2 - BACKGROUND: We report a meta-analysis of MRSA nasal colonization prevalence in children, and a review of the risk factors as well as molecular genetic characterization. METHODS: All relevant studies reporting prevalence data on MRSA nasal colonization in children published between January 2000 and August 2010 were retrieved from the MEDLINE database and analyzed. RESULTS: After screening 544 studies, 50 studies were included. We obtained an estimate of MRSA prevalence of 2.7% (CI 95%: 2.2-3.1); of 5.2% (CI 95%:3.1-7.3) in children with underlying conditions and of 2.3% (CI 95%: 1.8-2.7) in healthy children; 5.4% (CI 95%: 3.1-7.7) in children recruited in hospitals and 3% (CI 95%: 2.4-3.6) in children recruited in the community. SCCmecIV is the most diffused cassette globally. CONCLUSION: The hospital remains the environment where the microorganism circulates most. Children with underlying conditions could act as vectors of microorganisms between the hospital and the community. MRSA prevention strategies should be tailored to each specific institution, taking into account the nosocomial prevalence of MRSA nasal colonization and infections, and the prevalence of nasal colonization in the community that refers to the specific health care center.
AB - BACKGROUND: We report a meta-analysis of MRSA nasal colonization prevalence in children, and a review of the risk factors as well as molecular genetic characterization. METHODS: All relevant studies reporting prevalence data on MRSA nasal colonization in children published between January 2000 and August 2010 were retrieved from the MEDLINE database and analyzed. RESULTS: After screening 544 studies, 50 studies were included. We obtained an estimate of MRSA prevalence of 2.7% (CI 95%: 2.2-3.1); of 5.2% (CI 95%:3.1-7.3) in children with underlying conditions and of 2.3% (CI 95%: 1.8-2.7) in healthy children; 5.4% (CI 95%: 3.1-7.7) in children recruited in hospitals and 3% (CI 95%: 2.4-3.6) in children recruited in the community. SCCmecIV is the most diffused cassette globally. CONCLUSION: The hospital remains the environment where the microorganism circulates most. Children with underlying conditions could act as vectors of microorganisms between the hospital and the community. MRSA prevention strategies should be tailored to each specific institution, taking into account the nosocomial prevalence of MRSA nasal colonization and infections, and the prevalence of nasal colonization in the community that refers to the specific health care center.
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U2 - 10.1097/INF.0b013e3182864e4c
DO - 10.1097/INF.0b013e3182864e4c
M3 - Article
JO - Pediatric Infectious Disease Journal
JF - Pediatric Infectious Disease Journal
SN - 0891-3668
ER -