Abstract
Micro RNAs (miRNAs) are small non-coding RNAs, which dampen gene expression by repressing translation and/or inducing degradation of target-mRNAs. Although the role of miR-17-19b (a truncated version of miR-17-92 cluster) is well documented in MYC-driven B cell lymphomagenesis, little is known about the function of the cluster in the maintenance of full-blown lymphomas. We employed SILAC-based quantitative proteomics to identify miR-17-19b targets upon a mild overexpression of the cluster in B cell lymphomas, established from λ-MYC transgenic mice. The proteomics data described in detail in this study, whose follow up analysis with MaxQuant algorithm is part of the recent publication (Mihailovich et al., 2015) [1], are deposited to the ProteomeXchange Consortium via the PRIDE partner repository, with the accession code PRIDE: PXD002810.
Original language | English |
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Pages (from-to) | 349-353 |
Number of pages | 5 |
Journal | Data in Brief |
Volume | 7 |
DOIs | |
Publication status | Published - Jun 1 2016 |
Keywords
- B cell lymphoma
- Mass spectrometry
- MiR-17-92
- MiRNA targets
- MYC
- Quantitative proteomics
- SILAC
ASJC Scopus subject areas
- General
- Education