MSC and innate immune cell interactions: A lesson from human decidua

Paola Vacca, Elisa Montaldo, Chiara Vitale, Daniele Croxatto, Lorenzo Moretta, Maria Cristina Mingari

Research output: Contribution to journalArticlepeer-review

Abstract

Both experimental and clinical studies revealed that stromal cells (SC) are present in decidua (DSC) and placenta (PSC) at the early and late phase of pregnancy, respectively, and they may contribute to the induction of an anti-inflammatory/tolerogenic microenvironment crucial for the establishment/maintenance of successful pregnancy. These cells share common features with mesenchymal SC. In the present contribution, we provide an overall view on DSC features and on their ability to recruit NK cells and to regulate both differentiation and function not only of NK cells but also of CD14+ myeloid cells. NK cells represent the large majority of leukocytes populating decidual tissues during the first trimester of pregnancy. Their cross-talk with DSC is thought to play a key role in the establishment of feto-maternal tolerance. We also discuss recent data suggesting that DSC may contribute to tissue remodeling, placentation, and recruitment of leukocytes also through their interaction with innate lymphoid cells (ILC) such as ILC3, that have recently been shown to be present in decidual tissue.

Original languageEnglish
Pages (from-to)170-174
Number of pages5
JournalImmunology Letters
Volume168
Issue number2
DOIs
Publication statusPublished - Dec 1 2015

Keywords

  • Decidual stromal cells
  • Feto-maternal tolerance
  • Innate immunity
  • Innate lymphoid cells
  • NK cells
  • Pregnancy

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy

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