Abstract
Objective: To determine whether methylene tetrahydrofolate reductase (MTHFR) C677T mutation, factor II G20210A mutation and factor V Leiden are risk factors for retinal vein occlusion (RVO) in patients under fifty years of age. Methods: Comparison of 29 patients, under 50 years old of age, as affected RVO and 62 age matched normal controls. Plasma MTHFR C677T genotype, Factor II G20210A genotype, Factor V Leiden genotype, S protein level, C protein level, APCR presence (Actived Protein C Resistance), homocysteine level and Beta-thromboglobulin level were determined. Results: Seventeen RVO patients and twenty-one controls were heterozygous for the MTHFR C677T mutation. Three RVO patients and twenty-three controls were homozygous for the MTHFR C677T mutation. Three RVO patients and two controls were heterozygous for the factor II G20210A mutation. One control was heterozygous for the factor V Leiden. Conclusions: This study fails to demonstrate that these mutations are risk factors for RVO in patients under fifty years of age.
Original language | English |
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Pages (from-to) | 299-303 |
Number of pages | 5 |
Journal | Clinica Terapeutica |
Volume | 154 |
Issue number | 5 |
Publication status | Published - Sep 2003 |
Keywords
- Factor II G20210
- Factor V Leiden
- MTHFR C677T
- Retinal vein occlusion
ASJC Scopus subject areas
- Medicine(all)