TY - JOUR
T1 - MTOR, AMPK, and sirt1
T2 - Key players in metabolic stress management
AU - Cetrullo, Silvia
AU - D’Adamo, Stefania
AU - Tantini, Benedetta
AU - Borzì, Rosa Maria
AU - Flamigni, Flavio
PY - 2015
Y1 - 2015
N2 - Cells adapt their metabolism and activities in response to signals from their surroundings, and this ability is essential for their survival in the face of environmental changes. In mammalian tissues a deficit of these mechanisms is commonly associated with cellular aging and degenerative diseases related to aging, such as cardiovascular disease, cancer, immune system decline, and neurological pathologies. Several proteins have been identified as able to respond directly to energy, nutrient, and growth factor levels and stress stimuli in order to mediate adaptations in the cell. Many of these proteins are enzymes that positively or negatively modulate the autophagic process. This review focuses on biochemical mechanisms involving enzymes—specifically, mTOR, AMPK, and Sirt1—that are currently considered important for these adaptive responses, providing an overview of the interactions of the main players in this process.
AB - Cells adapt their metabolism and activities in response to signals from their surroundings, and this ability is essential for their survival in the face of environmental changes. In mammalian tissues a deficit of these mechanisms is commonly associated with cellular aging and degenerative diseases related to aging, such as cardiovascular disease, cancer, immune system decline, and neurological pathologies. Several proteins have been identified as able to respond directly to energy, nutrient, and growth factor levels and stress stimuli in order to mediate adaptations in the cell. Many of these proteins are enzymes that positively or negatively modulate the autophagic process. This review focuses on biochemical mechanisms involving enzymes—specifically, mTOR, AMPK, and Sirt1—that are currently considered important for these adaptive responses, providing an overview of the interactions of the main players in this process.
KW - AMPK
KW - Autophagy
KW - MTOR
KW - Sirt1
UR - http://www.scopus.com/inward/record.url?scp=84932135497&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84932135497&partnerID=8YFLogxK
M3 - Article
C2 - 25955819
AN - SCOPUS:84932135497
VL - 25
SP - 59
EP - 75
JO - Critical Reviews in Eukaryotic Gene Expression
JF - Critical Reviews in Eukaryotic Gene Expression
SN - 1045-4403
IS - 1
ER -