MTOR as a multifunctional therapeutic target in HIV infection

Ferdinando Nicoletti, Paolo Fagone, Pierluigi Meroni, James McCubrey, Klaus Bendtzen

Research output: Contribution to journalArticle

Abstract

Patients undergoing long-term highly active antiretroviral therapy treatment are probably at a higher risk of various HIV-related complications. Hyperactivation of The mammalian target of rapamycin (mTOR) has been found to contribute to dysregulated apoptosis and autophagy which determine CD4 +-T-cell loss, impaired function of innate immunity and development of neurocognitive disorders. Dysregulated mTOR activation has also been shown to play a key part in the development of nephropathy and in the pathogenesis of HIV-associated malignancies. These studies strongly support a multifunctional key role for mTOR in the pathogenesis of HIV-related disorders and suggest that specific mTOR inhibitors could represent a novel approach for the prevention and treatment of these pathologies.

Original languageEnglish
Pages (from-to)715-721
Number of pages7
JournalDrug Discovery Today
Volume16
Issue number15-16
DOIs
Publication statusPublished - Aug 2011

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ASJC Scopus subject areas

  • Drug Discovery
  • Pharmacology

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