MTR discloses subtle changes in the normal-appearing tissue from relatives of patients with MS

Malgorzata Siger-Zajdel, Massimo Filippi, Krzysztof Selmaj

Research output: Contribution to journalArticle


The presence of normal-appearing brain tissue (NABT) changes was investigated in 30 first-degree relatives of patients with MS, using magnetization transfer ratio (MTR) histograms. When compared with controls, relatives of patients with familial (p = 0.01) and sporadic (p = 0.01) MS had lower NABT MTR histogram peak heights. This study suggests a reduction of truly normal NABT in asymptomatic relatives of patients with MS.

Original languageEnglish
Pages (from-to)317-320
Number of pages4
Issue number2
Publication statusPublished - Jan 22 2002


ASJC Scopus subject areas

  • Neuroscience(all)

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