Mucosal and cutaneous human papillomaviruses in head and neck squamous cell papillomas

Maria Gabriella Donà, Barbara Pichi, Francesca Rollo, Tarik Gheit, Valentina Laquintana, Renato Covello, Edoardo Pescarmona, Giuseppe Spriano, Raul Pellini, Massimo Giuliani, Massimo Tommasino, Maria Benevolo

Research output: Contribution to journalArticlepeer-review


Background: Conflicting data exist regarding the contribution of human papillomavirus (HPV) to the development of head and neck squamous cell papillomas. Methods: Formalin-fixed paraffin-embedded papillomas were tested for 28 mucosal and 79 cutaneous HPVs using polymerase chain reaction (PCR)-based methods. Results: Eighty-three papillomas (43 oropharyngeal, 31 oral, 6 laryngeal, and 3 nasopharyngeal) were analyzed. Twenty-four samples (28.9%) harbored mucosal HPVs: 3 oropharyngeal (6.9%), 15 oral (48.3%), 4 laryngeal (66.7%), and 2 nasopharyngeal papillomas (66.7%). Eighty-one cases were also tested for cutaneous HPVs, detected in 16 lesions (19.7%): 11 (13.5%) harbored only cutaneous types, and 5 (6.2%) were positive for both cutaneous and mucosal HPVs. Among these 81 cases, prevalence of mucosal and/or cutaneous HPV infection was 43.2%. Conclusion: HPV DNA detection in a fraction of head and neck papillomas supports the role of HPV in their development. However, other markers need to be considered to confirm the association of HPV infection with these lesions.

Original languageEnglish
Pages (from-to)254-259
Number of pages6
JournalHead and Neck
Issue number2
Publication statusPublished - Feb 1 2017


  • oral cavity
  • oropharynx
  • papilloma
  • papillomavirus
  • prevalence

ASJC Scopus subject areas

  • Otorhinolaryngology


Dive into the research topics of 'Mucosal and cutaneous human papillomaviruses in head and neck squamous cell papillomas'. Together they form a unique fingerprint.

Cite this