Abstract
Background: Conflicting data exist regarding the contribution of human papillomavirus (HPV) to the development of head and neck squamous cell papillomas. Methods: Formalin-fixed paraffin-embedded papillomas were tested for 28 mucosal and 79 cutaneous HPVs using polymerase chain reaction (PCR)-based methods. Results: Eighty-three papillomas (43 oropharyngeal, 31 oral, 6 laryngeal, and 3 nasopharyngeal) were analyzed. Twenty-four samples (28.9%) harbored mucosal HPVs: 3 oropharyngeal (6.9%), 15 oral (48.3%), 4 laryngeal (66.7%), and 2 nasopharyngeal papillomas (66.7%). Eighty-one cases were also tested for cutaneous HPVs, detected in 16 lesions (19.7%): 11 (13.5%) harbored only cutaneous types, and 5 (6.2%) were positive for both cutaneous and mucosal HPVs. Among these 81 cases, prevalence of mucosal and/or cutaneous HPV infection was 43.2%. Conclusion: HPV DNA detection in a fraction of head and neck papillomas supports the role of HPV in their development. However, other markers need to be considered to confirm the association of HPV infection with these lesions.
| Original language | English |
|---|---|
| Pages (from-to) | 254-259 |
| Number of pages | 6 |
| Journal | Head and Neck |
| Volume | 39 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - Feb 1 2017 |
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Keywords
- oral cavity
- oropharynx
- papilloma
- papillomavirus
- prevalence
ASJC Scopus subject areas
- Otorhinolaryngology
Cite this
Mucosal and cutaneous human papillomaviruses in head and neck squamous cell papillomas. / Donà, Maria Gabriella; Pichi, Barbara; Rollo, Francesca; Gheit, Tarik; Laquintana, Valentina; Covello, Renato; Pescarmona, Edoardo; Spriano, Giuseppe; Pellini, Raul; Giuliani, Massimo; Tommasino, Massimo; Benevolo, Maria.
In: Head and Neck, Vol. 39, No. 2, 01.02.2017, p. 254-259.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Mucosal and cutaneous human papillomaviruses in head and neck squamous cell papillomas
AU - Donà, Maria Gabriella
AU - Pichi, Barbara
AU - Rollo, Francesca
AU - Gheit, Tarik
AU - Laquintana, Valentina
AU - Covello, Renato
AU - Pescarmona, Edoardo
AU - Spriano, Giuseppe
AU - Pellini, Raul
AU - Giuliani, Massimo
AU - Tommasino, Massimo
AU - Benevolo, Maria
PY - 2017/2/1
Y1 - 2017/2/1
N2 - Background: Conflicting data exist regarding the contribution of human papillomavirus (HPV) to the development of head and neck squamous cell papillomas. Methods: Formalin-fixed paraffin-embedded papillomas were tested for 28 mucosal and 79 cutaneous HPVs using polymerase chain reaction (PCR)-based methods. Results: Eighty-three papillomas (43 oropharyngeal, 31 oral, 6 laryngeal, and 3 nasopharyngeal) were analyzed. Twenty-four samples (28.9%) harbored mucosal HPVs: 3 oropharyngeal (6.9%), 15 oral (48.3%), 4 laryngeal (66.7%), and 2 nasopharyngeal papillomas (66.7%). Eighty-one cases were also tested for cutaneous HPVs, detected in 16 lesions (19.7%): 11 (13.5%) harbored only cutaneous types, and 5 (6.2%) were positive for both cutaneous and mucosal HPVs. Among these 81 cases, prevalence of mucosal and/or cutaneous HPV infection was 43.2%. Conclusion: HPV DNA detection in a fraction of head and neck papillomas supports the role of HPV in their development. However, other markers need to be considered to confirm the association of HPV infection with these lesions.
AB - Background: Conflicting data exist regarding the contribution of human papillomavirus (HPV) to the development of head and neck squamous cell papillomas. Methods: Formalin-fixed paraffin-embedded papillomas were tested for 28 mucosal and 79 cutaneous HPVs using polymerase chain reaction (PCR)-based methods. Results: Eighty-three papillomas (43 oropharyngeal, 31 oral, 6 laryngeal, and 3 nasopharyngeal) were analyzed. Twenty-four samples (28.9%) harbored mucosal HPVs: 3 oropharyngeal (6.9%), 15 oral (48.3%), 4 laryngeal (66.7%), and 2 nasopharyngeal papillomas (66.7%). Eighty-one cases were also tested for cutaneous HPVs, detected in 16 lesions (19.7%): 11 (13.5%) harbored only cutaneous types, and 5 (6.2%) were positive for both cutaneous and mucosal HPVs. Among these 81 cases, prevalence of mucosal and/or cutaneous HPV infection was 43.2%. Conclusion: HPV DNA detection in a fraction of head and neck papillomas supports the role of HPV in their development. However, other markers need to be considered to confirm the association of HPV infection with these lesions.
KW - oral cavity
KW - oropharynx
KW - papilloma
KW - papillomavirus
KW - prevalence
UR - http://www.scopus.com/inward/record.url?scp=85009160489&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85009160489&partnerID=8YFLogxK
U2 - 10.1002/hed.24575
DO - 10.1002/hed.24575
M3 - Article
C2 - 27618734
AN - SCOPUS:85009160489
VL - 39
SP - 254
EP - 259
JO - Head and Neck Surgery
JF - Head and Neck Surgery
SN - 1043-3074
IS - 2
ER -