Abstract
Background: Morphologic, histochemical, and cytoproliferative characteristics differentiate hyperplastic polyps from adenomas. Even so, these polyps are indicators of populations with a high colorectal cancer risk. Since changes in mucosal cell proliferation are highly predictive biomarkers of the adenoma-carcinoma sequence, this study examined the cytoproliferative profiles of mucosa bearing hyperplastic polyps, in a search for the significance of such lesions in bowel carcinogenesis. Methods: Proliferative activity demonstrated by immunohistochemical detection of the in vitro uptake of bromodeoxyuridine was evaluated in the rectal mucosa of 26 patients with hyperplastic polyps, 35 with adenomas
| Original language | English |
|---|---|
| Pages (from-to) | 344-348 |
| Number of pages | 5 |
| Journal | Scandinavian Journal of Gastroenterology |
| Volume | 30 |
| Issue number | 4 |
| DOIs | |
| Publication status | Published - 1995 |
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Keywords
- Bromodeoxyuridine
- Cell proliferation
- Colorectal cancer risk
- Hyperplastic polyps
- Rectal mucosa
ASJC Scopus subject areas
- Gastroenterology
Cite this
Mucosal cell proliferation in patients with hyperplastic colorectal polyps. / Risio, M.; Arrigoni, A.; Pennazio, M.; Agostinucci, A.; Spandre, M.; Rossini, F. P.
In: Scandinavian Journal of Gastroenterology, Vol. 30, No. 4, 1995, p. 344-348.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Mucosal cell proliferation in patients with hyperplastic colorectal polyps
AU - Risio, M.
AU - Arrigoni, A.
AU - Pennazio, M.
AU - Agostinucci, A.
AU - Spandre, M.
AU - Rossini, F. P.
PY - 1995
Y1 - 1995
N2 - Background: Morphologic, histochemical, and cytoproliferative characteristics differentiate hyperplastic polyps from adenomas. Even so, these polyps are indicators of populations with a high colorectal cancer risk. Since changes in mucosal cell proliferation are highly predictive biomarkers of the adenoma-carcinoma sequence, this study examined the cytoproliferative profiles of mucosa bearing hyperplastic polyps, in a search for the significance of such lesions in bowel carcinogenesis. Methods: Proliferative activity demonstrated by immunohistochemical detection of the in vitro uptake of bromodeoxyuridine was evaluated in the rectal mucosa of 26 patients with hyperplastic polyps, 35 with adenomas
AB - Background: Morphologic, histochemical, and cytoproliferative characteristics differentiate hyperplastic polyps from adenomas. Even so, these polyps are indicators of populations with a high colorectal cancer risk. Since changes in mucosal cell proliferation are highly predictive biomarkers of the adenoma-carcinoma sequence, this study examined the cytoproliferative profiles of mucosa bearing hyperplastic polyps, in a search for the significance of such lesions in bowel carcinogenesis. Methods: Proliferative activity demonstrated by immunohistochemical detection of the in vitro uptake of bromodeoxyuridine was evaluated in the rectal mucosa of 26 patients with hyperplastic polyps, 35 with adenomas
KW - Bromodeoxyuridine
KW - Cell proliferation
KW - Colorectal cancer risk
KW - Hyperplastic polyps
KW - Rectal mucosa
UR - http://www.scopus.com/inward/record.url?scp=0028947955&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0028947955&partnerID=8YFLogxK
U2 - 10.3109/00365529509093288
DO - 10.3109/00365529509093288
M3 - Article
C2 - 7610350
AN - SCOPUS:0028947955
VL - 30
SP - 344
EP - 348
JO - Scandinavian Journal of Gastroenterology
JF - Scandinavian Journal of Gastroenterology
SN - 0036-5521
IS - 4
ER -