Mucosal cell proliferation in patients with hyperplastic colorectal polyps

M. Risio; A. Arrigoni; M. Pennazio; A. Agostinucci; M. Spandre; F. P. Rossini

doi:10.3109/00365529509093288

Mucosal cell proliferation in patients with hyperplastic colorectal polyps

M. Risio, A. Arrigoni, M. Pennazio, A. Agostinucci, M. Spandre, F. P. Rossini

Istituto Oncologico Candiolo

Research output: Contribution to journal › Article › peer-review

Abstract

Background: Morphologic, histochemical, and cytoproliferative characteristics differentiate hyperplastic polyps from adenomas. Even so, these polyps are indicators of populations with a high colorectal cancer risk. Since changes in mucosal cell proliferation are highly predictive biomarkers of the adenoma-carcinoma sequence, this study examined the cytoproliferative profiles of mucosa bearing hyperplastic polyps, in a search for the significance of such lesions in bowel carcinogenesis. Methods: Proliferative activity demonstrated by immunohistochemical detection of the in vitro uptake of bromodeoxyuridine was evaluated in the rectal mucosa of 26 patients with hyperplastic polyps, 35 with adenomas

Original language	English
Pages (from-to)	344-348
Number of pages	5
Journal	Scandinavian Journal of Gastroenterology
Volume	30
Issue number	4
DOIs	https://doi.org/10.3109/00365529509093288
Publication status	Published - 1995

Keywords

Bromodeoxyuridine
Cell proliferation
Colorectal cancer risk
Hyperplastic polyps
Rectal mucosa

ASJC Scopus subject areas

Gastroenterology

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10.3109/00365529509093288

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title = "Mucosal cell proliferation in patients with hyperplastic colorectal polyps",

abstract = "Background: Morphologic, histochemical, and cytoproliferative characteristics differentiate hyperplastic polyps from adenomas. Even so, these polyps are indicators of populations with a high colorectal cancer risk. Since changes in mucosal cell proliferation are highly predictive biomarkers of the adenoma-carcinoma sequence, this study examined the cytoproliferative profiles of mucosa bearing hyperplastic polyps, in a search for the significance of such lesions in bowel carcinogenesis. Methods: Proliferative activity demonstrated by immunohistochemical detection of the in vitro uptake of bromodeoxyuridine was evaluated in the rectal mucosa of 26 patients with hyperplastic polyps, 35 with adenomas ",

keywords = "Bromodeoxyuridine, Cell proliferation, Colorectal cancer risk, Hyperplastic polyps, Rectal mucosa",

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year = "1995",

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T1 - Mucosal cell proliferation in patients with hyperplastic colorectal polyps

AU - Risio, M.

AU - Arrigoni, A.

AU - Pennazio, M.

AU - Agostinucci, A.

AU - Spandre, M.

AU - Rossini, F. P.

PY - 1995

Y1 - 1995

N2 - Background: Morphologic, histochemical, and cytoproliferative characteristics differentiate hyperplastic polyps from adenomas. Even so, these polyps are indicators of populations with a high colorectal cancer risk. Since changes in mucosal cell proliferation are highly predictive biomarkers of the adenoma-carcinoma sequence, this study examined the cytoproliferative profiles of mucosa bearing hyperplastic polyps, in a search for the significance of such lesions in bowel carcinogenesis. Methods: Proliferative activity demonstrated by immunohistochemical detection of the in vitro uptake of bromodeoxyuridine was evaluated in the rectal mucosa of 26 patients with hyperplastic polyps, 35 with adenomas

AB - Background: Morphologic, histochemical, and cytoproliferative characteristics differentiate hyperplastic polyps from adenomas. Even so, these polyps are indicators of populations with a high colorectal cancer risk. Since changes in mucosal cell proliferation are highly predictive biomarkers of the adenoma-carcinoma sequence, this study examined the cytoproliferative profiles of mucosa bearing hyperplastic polyps, in a search for the significance of such lesions in bowel carcinogenesis. Methods: Proliferative activity demonstrated by immunohistochemical detection of the in vitro uptake of bromodeoxyuridine was evaluated in the rectal mucosa of 26 patients with hyperplastic polyps, 35 with adenomas

KW - Bromodeoxyuridine

KW - Cell proliferation

KW - Colorectal cancer risk

KW - Hyperplastic polyps

KW - Rectal mucosa

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Mucosal cell proliferation in patients with hyperplastic colorectal polyps

Abstract

Keywords

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