Mucosal cell proliferation in patients with hyperplastic colorectal polyps

M. Risio, A. Arrigoni, M. Pennazio, A. Agostinucci, M. Spandre, F. P. Rossini

Research output: Contribution to journalArticle

Abstract

Background: Morphologic, histochemical, and cytoproliferative characteristics differentiate hyperplastic polyps from adenomas. Even so, these polyps are indicators of populations with a high colorectal cancer risk. Since changes in mucosal cell proliferation are highly predictive biomarkers of the adenoma-carcinoma sequence, this study examined the cytoproliferative profiles of mucosa bearing hyperplastic polyps, in a search for the significance of such lesions in bowel carcinogenesis. Methods: Proliferative activity demonstrated by immunohistochemical detection of the in vitro uptake of bromodeoxyuridine was evaluated in the rectal mucosa of 26 patients with hyperplastic polyps, 35 with adenomas

Original languageEnglish
Pages (from-to)344-348
Number of pages5
JournalScandinavian Journal of Gastroenterology
Volume30
Issue number4
DOIs
Publication statusPublished - 1995

Keywords

  • Bromodeoxyuridine
  • Cell proliferation
  • Colorectal cancer risk
  • Hyperplastic polyps
  • Rectal mucosa

ASJC Scopus subject areas

  • Gastroenterology

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  • Cite this

    Risio, M., Arrigoni, A., Pennazio, M., Agostinucci, A., Spandre, M., & Rossini, F. P. (1995). Mucosal cell proliferation in patients with hyperplastic colorectal polyps. Scandinavian Journal of Gastroenterology, 30(4), 344-348. https://doi.org/10.3109/00365529509093288