Abstract
Background: Morphologic, histochemical, and cytoproliferative characteristics differentiate hyperplastic polyps from adenomas. Even so, these polyps are indicators of populations with a high colorectal cancer risk. Since changes in mucosal cell proliferation are highly predictive biomarkers of the adenoma-carcinoma sequence, this study examined the cytoproliferative profiles of mucosa bearing hyperplastic polyps, in a search for the significance of such lesions in bowel carcinogenesis. Methods: Proliferative activity demonstrated by immunohistochemical detection of the in vitro uptake of bromodeoxyuridine was evaluated in the rectal mucosa of 26 patients with hyperplastic polyps, 35 with adenomas
| Original language | English |
|---|---|
| Pages (from-to) | 344-348 |
| Number of pages | 5 |
| Journal | Scandinavian Journal of Gastroenterology |
| Volume | 30 |
| Issue number | 4 |
| DOIs | |
| Publication status | Published - 1995 |
Keywords
- Bromodeoxyuridine
- Cell proliferation
- Colorectal cancer risk
- Hyperplastic polyps
- Rectal mucosa
ASJC Scopus subject areas
- Gastroenterology
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Cite this
Risio, M., Arrigoni, A., Pennazio, M., Agostinucci, A., Spandre, M., & Rossini, F. P. (1995). Mucosal cell proliferation in patients with hyperplastic colorectal polyps. Scandinavian Journal of Gastroenterology, 30(4), 344-348. https://doi.org/10.3109/00365529509093288