Abstract
Background: Morphologic, histochemical, and cytoproliferative characteristics differentiate hyperplastic polyps from adenomas. Even so, these polyps are indicators of populations with a high colorectal cancer risk. Since changes in mucosal cell proliferation are highly predictive biomarkers of the adenoma-carcinoma sequence, this study examined the cytoproliferative profiles of mucosa bearing hyperplastic polyps, in a search for the significance of such lesions in bowel carcinogenesis. Methods: Proliferative activity demonstrated by immunohistochemical detection of the in vitro uptake of bromodeoxyuridine was evaluated in the rectal mucosa of 26 patients with hyperplastic polyps, 35 with adenomas
Original language | English |
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Pages (from-to) | 344-348 |
Number of pages | 5 |
Journal | Scandinavian Journal of Gastroenterology |
Volume | 30 |
Issue number | 4 |
DOIs | |
Publication status | Published - 1995 |
Keywords
- Bromodeoxyuridine
- Cell proliferation
- Colorectal cancer risk
- Hyperplastic polyps
- Rectal mucosa
ASJC Scopus subject areas
- Gastroenterology