Mucosal expression of carcinoembryonic antigen and carbohydrate antigen 19-9 in patients with gastritis and gastric cancer

G. Esposito, A. Tempesta, M. G. Galati, M. De Bellis, G. B. Rossi, M. I. Potena, P. Marone, B. Daniele, S. Del Vecchio

Research output: Contribution to journalArticle

Abstract

Sixty-eight patients (45 males, 23 females) were studied in order to assess the usefulness of mucosal tissue concentrations of both carcinoembryonic antigen (CEA) and carbohydrate antigen 19-9 (CA 19-9) in detecting patients at high risk for gastric cancer. CEA and CA19-9 were assayed on cytosol obtained from multiple endoscopic biopsies of 41 patients with chronic superficial gastritis, 18 with chronic atrophic gastritis, and 9 with gastric cancer. Mucosal tissue concentrations of both CEA and CA19-9 increased from chronic superficial gastritis to chronic atrophic gastritis and to gastric cancer (p = 0.005 and p = 0.002, respectively). Mucosa] CEA levels in patients with intestinal metaplasia (IM) were significantly higher than in nonmetaplastic mucosa (p = 0.04). Epithelial dysplasia was associated with higher, though not significant, tissue concentrations of both CEA and CA19-9 when compared with IM. Finally, a correlation between serum levels and tissue concentrations was observed only for CA19-9 (Pearson's correlation coefficient = 0.7). In conclusion, these data indicate that gastric mucosa of patients with chronic atrophic gastritis and intestinal metaplasia express high levels of both CA 19-9 and CEA.

Original languageEnglish
Pages (from-to)116-122
Number of pages7
JournalCancer Detection and Prevention
Volume23
Issue number2
DOIs
Publication statusPublished - 1999

Keywords

  • Chronic atrophic gastritis
  • Dysplasia
  • Intestinal metaplasia
  • Precancerous conditions
  • Tumor markers

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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