Mucosal immunology and bacterial handling in the intestine

Research output: Contribution to journalArticle

Abstract

The mucosal immune system has the very difficult task to protect against invaders and to promote tolerance toward food antigens and the microbiota. These activities are achieved via a complex interaction between immune cells and the local microenvironment. Under the unperturbed (steady-state) condition the immune system is set toward the activation of tolerogenic responses. During infection the immune system is prompted to initiate immunity. When these two activities are not coordinated, inflammatory conditions may arise. In this review I will summarize the characteristic features of the mucosal immune system and its interaction with the microbiota.

Original languageEnglish
Pages (from-to)17-24
Number of pages8
JournalBailliere's Best Practice and Research in Clinical Gastroenterology
Volume27
Issue number1
DOIs
Publication statusPublished - Feb 2013

Keywords

  • Dendritic cells
  • Microbiota
  • Mucosal immunity

ASJC Scopus subject areas

  • Gastroenterology

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