Multi-center comparison of medial temporal atrophy in patients with Alzheimer's disease - Data from the ICTUS study

Samantha Galluzzi, Erika Talassi, Michela Belussi, Philip Scheltens, Laura Van De Pol, Flavio Nobili, Guido Rodriguez, Lutz Froelich, Marinella Damian, Pablo Martinez-Lage, Teresa Gomez-Isla, Emma Reynish, Pierre Jean Ousset, Bruno Vellas, Giovanni B. Frisoni

Research output: Contribution to journalArticlepeer-review


Objective: To study multi-center variability of medial temporal lobe atrophy (MTA) in patients with Alzheimer's disease (AD) recruited in a European observational study of AD. Methods: 117 mild to moderate AD patients from 5 European centers (Amsterdam, The Netherlands; Brescia and Genova, Italy; Mannheim, Germany; Pamplona, Spain) had magnetic resonance imaging scans performed as part of the routine diagnostic examination. MTA was assessed with the visual Scheltens scale. Results: AD patients from Brescia, Genova, Pamplona, and Mannheim had a mean 32% prevalence of no or borderline MTA vs. 62% of patients from Amsterdam (p = 0.002 for the difference between Amsterdam and all the other centers). The peculiar distribution of MTA in the Amsterdam patients may be attributable to younger age (70.7 ± 8.4 vs. 75.3 ± 6.8 years, p = 0.002), milder dementia severity (score 0.5 on the clinical dementia rating scale: 52 vs. 23%, p = 0.003), and less frequent depression (14 vs. 49%, p <0.0005 in Amsterdam vs. all the other centers, respectively). Conclusion: Patients with probable AD recruited in different centers of Europe generally have similar MTA distribution, even if peculiar demographic and clinical findings might explain occasional differences. These results have implications for clinical trials in AD with biological markers as outcome measures.

Original languageEnglish
Pages (from-to)314-322
Number of pages9
JournalDementia and Geriatric Cognitive Disorders
Issue number4
Publication statusPublished - Oct 2008


  • Alzheimer's disease
  • Atrophy
  • European Alzheimer's Disease Consortium (EADC)
  • ICTUS study
  • Magnetic resonance imaging
  • Medial temporal lobe
  • Rating scale

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Geriatrics and Gerontology
  • Cognitive Neuroscience


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