Multi-drugs resistant acne rosacea in a child affected by Ataxia-Telangiectasia: Successful treatment with Isotretinoin Allergology and Immunology

Nicoletta Cantarutti, Alessia Claps, Giulia Angelino, Luciana Chessa, Francesco Callea, May El Hachem, Andrea Diociaiuti, Andrea Finocchi

Research output: Contribution to journalArticlepeer-review

Abstract

Ataxia-Telangiectasia is a rare multisystem autosomal recessive disorder [OMIM 208900], caused by mutations in Ataxia-Telangiectasia Mutated gene. It is characterized by neurological, immunological and cutaneous involvement. Granulomas have been previously reported in Ataxia-Telangiectasia patients, even if acne rosacea has not been described. We report a case of a young Ataxia-Telangiectasia patient with a severe immunological and neurological involvement, who developed granulomatous skin lesions diagnosed by skin biopsy as acne rosacea. Considering the severe clinical picture and the lack of improvement to multiple topic and systemic therapies, treatment with Isotretinoin was started and the skin lesions disappeared after five months. However the therapy was stopped due to drug-hepatotoxicity. Systemic treatment with Isotretinoin should be carefully considered in patient with Ataxia-Telangiectasia for the treatment of multi-drug resistant acne rosacea, however its toxicity may limit long-term use and the risk/benefit ratio of the treatment should be evaluated.

Original languageEnglish
Article number23
JournalItalian Journal of Pediatrics
Volume41
Issue number1
DOIs
Publication statusPublished - Mar 28 2015

Keywords

  • Acne rosacea
  • Ataxia-telangiectasia
  • Granulomas
  • Isotretinoin

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

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