Multi-Institutional External Validation of Seminal Vesicle Invasion Nomograms: Head-to-Head Comparison of Gallina Nomogram Versus 2007 Partin Tables

Kevin C. Zorn, Umberto Capitanio, Claudio Jeldres, Philippe Arjane, Paul Perrotte, Shahrokh F. Shariat, David I. Lee, Arieh L. Shalhav, Gregory P. Zagaja, Sergey A. Shikanov, Ofer N. Gofrit, Alan E. Thong, David M. Albala, Leon Sun, Pierre I. Karakiewicz

Research output: Contribution to journalArticle

Abstract

Purpose: The Partin tables represent one of the most widely used prostate cancer staging tools for seminal vesicle invasion (SVI) prediction. Recently, Gallina et al. reported a novel staging tool for the prediction of SVI that further incorporated the use of the percentage of positive biopsy cores. We performed an external validation of the Gallina et al. nomogram and the 2007 Partin tables in a large, multi-institutional North American cohort of men treated with robotic-assisted radical prostatectomy. Methods and Materials: Clinical and pathologic data were prospectively gathered from 2,606 patients treated with robotic-assisted radical prostatectomy at one of four North American robotic referral centers between 2002 and 2007. Discrimination was quantified with the area under the receiver operating characteristics curve. The calibration compared the predicted and observed SVI rates throughout the entire range of predictions. Results: At robotic-assisted radical prostatectomy, SVI was recorded in 4.2% of patients. The discriminant properties of the Gallina et al. nomogram resulted in 81% accuracy compared with 78% for the 2007 Partin tables. The Gallina et al. nomogram overestimated the true rate of SVI. Conversely, the Partin tables underestimated the true rate of SVI. Conclusion: The Gallina et al. nomogram offers greater accuracy (81%) than the 2007 Partin tables (78%). However, both tools are associated with calibration limitations that need to be acknowledged and considered before their implementation into clinical practice.

Original languageEnglish
Pages (from-to)1461-1467
Number of pages7
JournalInternational Journal of Radiation Oncology Biology Physics
Volume73
Issue number5
DOIs
Publication statusPublished - Apr 1 2009

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Keywords

  • Nomogram
  • Prostate cancer
  • Robotic-assisted laparoscopic prostatectomy
  • Seminal vesicle invasion

ASJC Scopus subject areas

  • Cancer Research
  • Oncology
  • Radiology Nuclear Medicine and imaging
  • Radiation

Cite this

Zorn, K. C., Capitanio, U., Jeldres, C., Arjane, P., Perrotte, P., Shariat, S. F., Lee, D. I., Shalhav, A. L., Zagaja, G. P., Shikanov, S. A., Gofrit, O. N., Thong, A. E., Albala, D. M., Sun, L., & Karakiewicz, P. I. (2009). Multi-Institutional External Validation of Seminal Vesicle Invasion Nomograms: Head-to-Head Comparison of Gallina Nomogram Versus 2007 Partin Tables. International Journal of Radiation Oncology Biology Physics, 73(5), 1461-1467. https://doi.org/10.1016/j.ijrobp.2008.06.1913