Multi-layer picture of neurodegenerative diseases: Lessons from the use of big data through artificial intelligence

Andrea Termine, Carlo Fabrizio, Claudia Strafella, Valerio Caputo, Laura Petrosini, Carlo Caltagirone, Emiliano Giardina, Raffaella Cascella

Research output: Contribution to journalReview articlepeer-review


In the big data era, artificial intelligence techniques have been applied to tackle traditional issues in the study of neurodegenerative diseases. Despite the progress made in understanding the complex (epi)genetics signatures underlying neurodegenerative disorders, performing early diagnosis and developing drug repurposing strategies remain serious challenges for such conditions. In this context, the integration of multi-omics, neuroimaging, and electronic health records data can be exploited using deep learning methods to provide the most accurate representation of patients possible. Deep learning allows researchers to find multi-modal biomarkers to develop more effective and personalized treatments, early diagnosis tools, as well as useful information for drug discovering and repurposing in neurodegenerative pathologies. In this review, we will describe how relevant studies have been able to demonstrate the potential of deep learning to enhance the knowledge of neurodegenerative disorders such as Alzheimer’s and Parkinson’s diseases through the integration of all sources of biomedical data.

Original languageEnglish
Article number280
JournalJournal of Personalized Medicine
Issue number4
Publication statusPublished - 2021


  • Artificial intelligence
  • Big data
  • Deep learning
  • Neurodegenerative diseases
  • Precision medicine

ASJC Scopus subject areas

  • Medicine (miscellaneous)


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