Multi-nuclear MRS and 19F MRI of 19F-labelled and 10B-enriched p-boronophenylalanine-fructose complex to optimize boron neutron capture therapy: Phantom studies at high magnetic fields

Paola Porcari, Silvia Capuani, Renzo Campanella, Angela La Bella, Luisa Maria Migneco, Bruno Maraviglia

Research output: Contribution to journalArticle

Abstract

Reaction yield optimization for the synthesis and the complexation of a boron neutron capture therapy agent 19F-labelled, 10B-enriched p-boronophenylalanine-fructose (19F-BPA-fr) complex was obtained. 1H, 19F, 13C and 10B magnetic resonance spectroscopy (MRS) of the 19F-BPA- fr complex in aqueous and rat blood solution phantoms and its spatial distribution mapping using 19F magnetic resonance imaging (MRI) results are reported. 7 T and 9.4 T magnetic fields were used to perform MRI and MRS respectively. Our in vitro results suggest that in vivo studies on 19F-BPA through 19F NMR will be feasible.

Original languageEnglish
Pages (from-to)3141-3154
Number of pages14
JournalPhysics in Medicine and Biology
Volume51
Issue number12
DOIs
Publication statusPublished - Jun 21 2006

ASJC Scopus subject areas

  • Biomedical Engineering
  • Physics and Astronomy (miscellaneous)
  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology

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