TY - JOUR
T1 - Multi-nuclear MRS and 19F MRI of 19F-labelled and 10B-enriched p-boronophenylalanine-fructose complex to optimize boron neutron capture therapy
T2 - Phantom studies at high magnetic fields
AU - Porcari, Paola
AU - Capuani, Silvia
AU - Campanella, Renzo
AU - La Bella, Angela
AU - Migneco, Luisa Maria
AU - Maraviglia, Bruno
PY - 2006/6/21
Y1 - 2006/6/21
N2 - Reaction yield optimization for the synthesis and the complexation of a boron neutron capture therapy agent 19F-labelled, 10B-enriched p-boronophenylalanine-fructose (19F-BPA-fr) complex was obtained. 1H, 19F, 13C and 10B magnetic resonance spectroscopy (MRS) of the 19F-BPA- fr complex in aqueous and rat blood solution phantoms and its spatial distribution mapping using 19F magnetic resonance imaging (MRI) results are reported. 7 T and 9.4 T magnetic fields were used to perform MRI and MRS respectively. Our in vitro results suggest that in vivo studies on 19F-BPA through 19F NMR will be feasible.
AB - Reaction yield optimization for the synthesis and the complexation of a boron neutron capture therapy agent 19F-labelled, 10B-enriched p-boronophenylalanine-fructose (19F-BPA-fr) complex was obtained. 1H, 19F, 13C and 10B magnetic resonance spectroscopy (MRS) of the 19F-BPA- fr complex in aqueous and rat blood solution phantoms and its spatial distribution mapping using 19F magnetic resonance imaging (MRI) results are reported. 7 T and 9.4 T magnetic fields were used to perform MRI and MRS respectively. Our in vitro results suggest that in vivo studies on 19F-BPA through 19F NMR will be feasible.
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U2 - 10.1088/0031-9155/51/12/010
DO - 10.1088/0031-9155/51/12/010
M3 - Article
C2 - 16757868
AN - SCOPUS:33745089021
VL - 51
SP - 3141
EP - 3154
JO - Physics in Medicine and Biology
JF - Physics in Medicine and Biology
SN - 0031-9155
IS - 12
ER -