Multi-nuclear MRS and 19F MRI of 19F-labelled and 10B-enriched p-boronophenylalanine-fructose complex to optimize boron neutron capture therapy: Phantom studies at high magnetic fields

Paola Porcari; Silvia Capuani; Renzo Campanella; Angela La Bella; Luisa Maria Migneco; Bruno Maraviglia

doi:10.1088/0031-9155/51/12/010

Multi-nuclear MRS and 19F MRI of 19F-labelled and 10B-enriched p-boronophenylalanine-fructose complex to optimize boron neutron capture therapy: Phantom studies at high magnetic fields

Paola Porcari, Silvia Capuani, Renzo Campanella, Angela La Bella, Luisa Maria Migneco, Bruno Maraviglia

Fondazione Santa Lucia

Research output: Contribution to journal › Article

Abstract

Reaction yield optimization for the synthesis and the complexation of a boron neutron capture therapy agent ¹⁹F-labelled, ¹⁰B-enriched p-boronophenylalanine-fructose (¹⁹F-BPA-fr) complex was obtained. ¹H, ¹⁹F, ¹³C and ¹⁰B magnetic resonance spectroscopy (MRS) of the ¹⁹F-BPA- fr complex in aqueous and rat blood solution phantoms and its spatial distribution mapping using ¹⁹F magnetic resonance imaging (MRI) results are reported. 7 T and 9.4 T magnetic fields were used to perform MRI and MRS respectively. Our in vitro results suggest that in vivo studies on ¹⁹F-BPA through ¹⁹F NMR will be feasible.

Original language	English
Pages (from-to)	3141-3154
Number of pages	14
Journal	Physics in Medicine and Biology
Volume	51
Issue number	12
DOIs	https://doi.org/10.1088/0031-9155/51/12/010
Publication status	Published - Jun 21 2006

ASJC Scopus subject areas

Biomedical Engineering
Physics and Astronomy (miscellaneous)
Radiology Nuclear Medicine and imaging
Radiological and Ultrasound Technology

Access to Document

10.1088/0031-9155/51/12/010

Fingerprint Dive into the research topics of 'Multi-nuclear MRS and 19F MRI of 19F-labelled and 10B-enriched p-boronophenylalanine-fructose complex to optimize boron neutron capture therapy: Phantom studies at high magnetic fields'. Together they form a unique fingerprint.

Cite this

Porcari, P., Capuani, S., Campanella, R., La Bella, A., Migneco, L. M., & Maraviglia, B. (2006). Multi-nuclear MRS and 19F MRI of 19F-labelled and 10B-enriched p-boronophenylalanine-fructose complex to optimize boron neutron capture therapy: Phantom studies at high magnetic fields. Physics in Medicine and Biology, 51(12), 3141-3154. https://doi.org/10.1088/0031-9155/51/12/010

Multi-nuclear MRS and 19F MRI of 19F-labelled and 10B-enriched p-boronophenylalanine-fructose complex to optimize boron neutron capture therapy : Phantom studies at high magnetic fields. / Porcari, Paola; Capuani, Silvia; Campanella, Renzo; La Bella, Angela; Migneco, Luisa Maria; Maraviglia, Bruno.

In: Physics in Medicine and Biology, Vol. 51, No. 12, 21.06.2006, p. 3141-3154.

Research output: Contribution to journal › Article

Porcari, P, Capuani, S, Campanella, R, La Bella, A, Migneco, LM & Maraviglia, B 2006, 'Multi-nuclear MRS and 19F MRI of 19F-labelled and 10B-enriched p-boronophenylalanine-fructose complex to optimize boron neutron capture therapy: Phantom studies at high magnetic fields', Physics in Medicine and Biology, vol. 51, no. 12, pp. 3141-3154. https://doi.org/10.1088/0031-9155/51/12/010

Porcari, Paola ; Capuani, Silvia ; Campanella, Renzo ; La Bella, Angela ; Migneco, Luisa Maria ; Maraviglia, Bruno. / Multi-nuclear MRS and 19F MRI of 19F-labelled and 10B-enriched p-boronophenylalanine-fructose complex to optimize boron neutron capture therapy : Phantom studies at high magnetic fields. In: Physics in Medicine and Biology. 2006 ; Vol. 51, No. 12. pp. 3141-3154.

@article{6f5d9dde1b294213bf80abdebd005c41,

title = "Multi-nuclear MRS and 19F MRI of 19F-labelled and 10B-enriched p-boronophenylalanine-fructose complex to optimize boron neutron capture therapy: Phantom studies at high magnetic fields",

abstract = "Reaction yield optimization for the synthesis and the complexation of a boron neutron capture therapy agent 19F-labelled, 10B-enriched p-boronophenylalanine-fructose (19F-BPA-fr) complex was obtained. 1H, 19F, 13C and 10B magnetic resonance spectroscopy (MRS) of the 19F-BPA- fr complex in aqueous and rat blood solution phantoms and its spatial distribution mapping using 19F magnetic resonance imaging (MRI) results are reported. 7 T and 9.4 T magnetic fields were used to perform MRI and MRS respectively. Our in vitro results suggest that in vivo studies on 19F-BPA through 19F NMR will be feasible.",

author = "Paola Porcari and Silvia Capuani and Renzo Campanella and {La Bella}, Angela and Migneco, {Luisa Maria} and Bruno Maraviglia",

year = "2006",

month = jun,

day = "21",

doi = "10.1088/0031-9155/51/12/010",

language = "English",

volume = "51",

pages = "3141--3154",

journal = "Physics in Medicine and Biology",

issn = "0031-9155",

publisher = "IOP Publishing Ltd.",

number = "12",

}

TY - JOUR

T1 - Multi-nuclear MRS and 19F MRI of 19F-labelled and 10B-enriched p-boronophenylalanine-fructose complex to optimize boron neutron capture therapy

T2 - Phantom studies at high magnetic fields

AU - Porcari, Paola

AU - Capuani, Silvia

AU - Campanella, Renzo

AU - La Bella, Angela

AU - Migneco, Luisa Maria

AU - Maraviglia, Bruno

PY - 2006/6/21

Y1 - 2006/6/21

N2 - Reaction yield optimization for the synthesis and the complexation of a boron neutron capture therapy agent 19F-labelled, 10B-enriched p-boronophenylalanine-fructose (19F-BPA-fr) complex was obtained. 1H, 19F, 13C and 10B magnetic resonance spectroscopy (MRS) of the 19F-BPA- fr complex in aqueous and rat blood solution phantoms and its spatial distribution mapping using 19F magnetic resonance imaging (MRI) results are reported. 7 T and 9.4 T magnetic fields were used to perform MRI and MRS respectively. Our in vitro results suggest that in vivo studies on 19F-BPA through 19F NMR will be feasible.

AB - Reaction yield optimization for the synthesis and the complexation of a boron neutron capture therapy agent 19F-labelled, 10B-enriched p-boronophenylalanine-fructose (19F-BPA-fr) complex was obtained. 1H, 19F, 13C and 10B magnetic resonance spectroscopy (MRS) of the 19F-BPA- fr complex in aqueous and rat blood solution phantoms and its spatial distribution mapping using 19F magnetic resonance imaging (MRI) results are reported. 7 T and 9.4 T magnetic fields were used to perform MRI and MRS respectively. Our in vitro results suggest that in vivo studies on 19F-BPA through 19F NMR will be feasible.

UR - http://www.scopus.com/inward/record.url?scp=33745089021&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33745089021&partnerID=8YFLogxK

U2 - 10.1088/0031-9155/51/12/010

DO - 10.1088/0031-9155/51/12/010

M3 - Article

C2 - 16757868

AN - SCOPUS:33745089021

VL - 51

SP - 3141

EP - 3154

JO - Physics in Medicine and Biology

JF - Physics in Medicine and Biology

SN - 0031-9155

IS - 12

ER -