Multicenter analysis of pathological outcomes of patients eligible for active surveillance according to PRIAS criteria

Angelica A C Grasso, Gabriele Cozzi, Elisa De Lorenzis, Carlo Ceruti, Simone Crivellaro, Mario Falsaperla, Andrea Minervini, Lorenzo Masieri, Angelo Porreca, Stefano Zaramella, Bernardo Rocco

Research output: Contribution to journalArticle

Abstract

BACKGROUND: The aim of this study was to retrospectively analyze the pathological outcomes of patients meeting the Prostate Cancer Research International Active Surveillance (PRIAS) criteria who had undergone radical prostatectomy (RP). METHODS: Out of 2014 patients recruited for minimally invasive RP between 2008 and 2014 in 7 centers, 226 (11.2%) met the modified PRIAS criteria (clinical stage T1c/T2, PSA>10 ng/mL, 1-2 positive biopsy cores and Gleason Score>6). RESULTS: At pathological evaluation, Gleason Score upgrade was reported in 47.3% of patients; 74 (32.7%), 10 (4.4%), 9 (3.9%) patients showed RP Gleason sum 7, 8 and 9, respectively. Upstaging was reported in 135 patients (59.7%). Twelve (5.3%) and 4 (1.7%) patients had T3a and T3b pathological stage respectively. CONCLUSIONS: Notwithstanding the PRIAS criteria can identify some PCa patients as low-risk, at pathological evaluation some of them harbored intermediate- or high-risk disease. According to our data, patients eligible for AS should be carefully counseled about possible disease understaging.

Original languageEnglish
Pages (from-to)237-241
Number of pages5
JournalMinerva Urologica e Nefrologica
Volume68
Issue number3
Publication statusPublished - Jun 1 2016

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Prostatic Neoplasms
Research
Prostatectomy
Neoplasm Grading
Biopsy

Keywords

  • Prostatectomy
  • Prostatic neoplasms
  • Watchful waiting

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Grasso, A. A. C., Cozzi, G., De Lorenzis, E., Ceruti, C., Crivellaro, S., Falsaperla, M., ... Rocco, B. (2016). Multicenter analysis of pathological outcomes of patients eligible for active surveillance according to PRIAS criteria. Minerva Urologica e Nefrologica, 68(3), 237-241.

Multicenter analysis of pathological outcomes of patients eligible for active surveillance according to PRIAS criteria. / Grasso, Angelica A C; Cozzi, Gabriele; De Lorenzis, Elisa; Ceruti, Carlo; Crivellaro, Simone; Falsaperla, Mario; Minervini, Andrea; Masieri, Lorenzo; Porreca, Angelo; Zaramella, Stefano; Rocco, Bernardo.

In: Minerva Urologica e Nefrologica, Vol. 68, No. 3, 01.06.2016, p. 237-241.

Research output: Contribution to journalArticle

Grasso, AAC, Cozzi, G, De Lorenzis, E, Ceruti, C, Crivellaro, S, Falsaperla, M, Minervini, A, Masieri, L, Porreca, A, Zaramella, S & Rocco, B 2016, 'Multicenter analysis of pathological outcomes of patients eligible for active surveillance according to PRIAS criteria', Minerva Urologica e Nefrologica, vol. 68, no. 3, pp. 237-241.
Grasso, Angelica A C ; Cozzi, Gabriele ; De Lorenzis, Elisa ; Ceruti, Carlo ; Crivellaro, Simone ; Falsaperla, Mario ; Minervini, Andrea ; Masieri, Lorenzo ; Porreca, Angelo ; Zaramella, Stefano ; Rocco, Bernardo. / Multicenter analysis of pathological outcomes of patients eligible for active surveillance according to PRIAS criteria. In: Minerva Urologica e Nefrologica. 2016 ; Vol. 68, No. 3. pp. 237-241.
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