Multicenter case-control study of exposure to environmental tobacco smoke and lung cancer in Europe

Paolo Boffetta, Antonio Agudo, Wolfgang Ahrens, Ellen Benhamou, Simone Benhamou, Sarah C. Darby, Gilles Ferro, Cristina Fortes, Carlos A. Gonzalez, Karl Heinz Jöckel, Martin Krauss, Lothar Kreienbrock, Michaela Kreuzer, Anabela Mendes, Franco Merletti, Fredrik Nyberg, Göran Pershagen, Hermann Pohlabeln, Elio Riboli, Giovanni SchmidLorenzo Simonato, Jean Trédaniel, Elise Whitley, Heinz Erich Wichmann, Carlos Winck, Paola Zambon, Rodolfo Saracci

Research output: Contribution to journalArticle

Abstract

Background: An association between exposure to environmental tobacco smoke (ETS) and lung cancer risk has been suggested. To evaluate this possible association better, researchers need more precise estimates of risk, the relative contribution of different sources of ETS, and the effect of ETS exposure on different histologic types of lung cancer. To address these issues, we have conducted a case-control study of lung cancer and exposure to ETS in 12 centers from seven European countries. Methods: A total of 650 patients with lung cancer and 1542 control subjects up to 74 years of age were interviewed about exposure to ETS. Neither case subjects nor control subjects had smoked more than 400 cigarettes in their lifetime. Results: ETS exposure during childhood was not associated with an increased risk of lung cancer (odds ratio [OR] for ever exposure = 0.78; 95% confidence interval [CI] = 0.64-096). The OR for ever exposure to spousal ETS was 1.16 (95% CI = 0.93-1.44). No clear dose-response relationship could be demonstrated for cumulative spousal ETS exposure. The OR for ever exposure to workplace ETS was 1.17 (95% CI = 0.94-1.45), with possible evidence of increasing risk for increasing duration of exposure. No increase in risk was detected in subjects whose exposure to spousal or workplace ETS ended more than 15 years earlier. Ever exposure to ETS from other sources was not associated with lung cancer risk. Risks from combined exposure to spousal and workplace ETS were higher for squamous cell carcinoma and small-cell carcinoma than for adenocarcinoma, but the differences were not statistically significant. Conclusions: Our results indicate no association between childhood exposure to ETS and lung cancer risk. We did find weak evidence of a dose-response relationship between risk of lung cancer and exposure to spousal and workplace ETS. There was no detectable risk after cessation of exposure.

Original languageEnglish
Pages (from-to)1440-1450
Number of pages11
JournalJournal of the National Cancer Institute
Volume90
Issue number19
Publication statusPublished - Oct 7 1998

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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    Boffetta, P., Agudo, A., Ahrens, W., Benhamou, E., Benhamou, S., Darby, S. C., Ferro, G., Fortes, C., Gonzalez, C. A., Jöckel, K. H., Krauss, M., Kreienbrock, L., Kreuzer, M., Mendes, A., Merletti, F., Nyberg, F., Pershagen, G., Pohlabeln, H., Riboli, E., ... Saracci, R. (1998). Multicenter case-control study of exposure to environmental tobacco smoke and lung cancer in Europe. Journal of the National Cancer Institute, 90(19), 1440-1450.