Multicenter evaluation of a whole-blood filter that saves platelets

Dragica Paunovic, Pieter Van Der Meer, Jens Kjeldsen-Kragh, Riitta Kekomaki, Stella Larsson, Noemi Greppi, Laura Porretti, Bela Balint, Miroljub Trkuljic, Ninoslav Nedeljkovic, Ruzica Simonovic, Anna Massaro, Luciana Labanca, Shinichi Kora, Joachim Riggert

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Abstract

BACKGROUND: Whole-blood (WB) leukoreduction filters in current use retain the majority of PLTs. A new whole-blood filter, which retains significantly fewer of the PLTs (or saves PLTs [WB-SP]), has been developed. The performance characteristics of the WB-SP filter have been evaluated in a multicenter study. STUDY DESIGN AND METHODS: A total of 617 units of WB was collected into quadruple bag sets with an integrated WB-SP filter, leukoreduced, and processed into leukoreduced RBCs (LR-RBC), plasma (LR-PL), and buffy coats (LR-BC) from which, pooled, leukoreduced, PLT concentrates (LR-PCs) were produced. Recovery, yield, and residual WBCs were assessed in prepared blood components. RESULTS: The median residual WBC number in the LR-RBCs was 0.05 × 106 (range, 6 in 0.6 percent of the units. Median Hb content in LR-RBC was 50 g (range, 34-72), reflecting a final RBC recovery of 81 ± 6 percent. The median WBC content of the LR-PC was 0.05 × 106 (range, 6. The median PLT content of the LR-PC, per individual donation, was 6.4 × 1010 (range, 4.1-10.7), representing a final recovery of 62 ± 10 percent. The mean FVIII activity was 104 ± 25 percent and 83 ± 11 percent in plasma separated from fresh or overnight stored WB, respectively. CONCLUSION: Use of the WB-SP filter makes it possible to obtain three leukoreduced blood components with only one filtration step. The WB-SP filter showed good leukoreduction performance and recovery of all blood components including PLTs.

Original languageEnglish
Pages (from-to)1197-1203
Number of pages7
JournalTransfusion
Volume44
Issue number8
DOIs
Publication statusPublished - Aug 2004

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ASJC Scopus subject areas

  • Hematology
  • Immunology

Cite this

Paunovic, D., Van Der Meer, P., Kjeldsen-Kragh, J., Kekomaki, R., Larsson, S., Greppi, N., Porretti, L., Balint, B., Trkuljic, M., Nedeljkovic, N., Simonovic, R., Massaro, A., Labanca, L., Kora, S., & Riggert, J. (2004). Multicenter evaluation of a whole-blood filter that saves platelets. Transfusion, 44(8), 1197-1203. https://doi.org/10.1111/j.1537-2995.2004.03350.x