Multicenter studies of brain morphometry

Fabrizio Piras, Mariangela Iorio, Daniela Vecchio, Tommaso Gili, Fabrizio Piras, Gianfranco Spalletta

Research output: Chapter in Book/Report/Conference proceedingChapter


Methods enabling the characterization of brain morphometry have evolved exponentially in the last decades and have been shown important clinical applications. First MRI studies usually included a low number of subjects, but later on, it has become recognized that efforts from different research centers can be pooled by combining data acquisition and analyses toward large-scale collaborative projects. Large-scale studies have a number of advantages, with the most intuitive being the increase in the number of enrolled subjects and, consequently, statistical power. However, there are also a number of caveats including (but not limited to) the high cost in terms of human and economic resources and the intrinsic variation of acquired data linked to the different MRI technologies. This chapter depicts the different categories of large-scale studies, according to the level of control and planning on data acquisition and analyses. It also describes the most relevant multicenter studies, from the first precursor consortia in the early 1990s to the most recent worldwide multimodal collaborative efforts.

Original languageEnglish
Title of host publicationNeuromethods
PublisherHumana Press Inc.
Number of pages12
Publication statusPublished - Jan 1 2018
Externally publishedYes

Publication series

ISSN (Print)0893-2336
ISSN (Electronic)1940-6045


  • Brain morphology
  • Data sharing
  • Mega-analysis
  • Meta-analysis
  • MRI
  • Multicenter studies
  • Neuroinformatics

ASJC Scopus subject areas

  • Neuroscience(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)
  • Psychiatry and Mental health


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