Abstract
Human papillomaviruses (betaPV) from the beta genus cannot be classified according to their oncogenicity due to a paucity of information. This study evaluates the association between betaPV infection and cutaneous squamous cell carcinoma in conjunction with measures of UV exposure and susceptibility. We performed case-control studies in the Netherlands, Italy, and Australia, countries with profoundly different UV exposures. The presence of 25 betaPV types in eyebrow hair follicles was determined using a highly sensitive HPV DNA genotyping assay, and antibodies for the 15 most prevalent betaPV types in a total of 689 squamous cell carcinoma cases and 845 controls were detected using multiplex serology. Multivariate logistic regression models were used for case-control comparisons and interaction analyses. BetaPV DNA was detected in eyebrow hairs of more than 90% of all participants. The presence of betaPV DNA was associated with an increased risk of squamous cell carcinoma in the Netherlands (OR = 2.8; 95% CI 1.3-5.8) and Italy (OR = 1.7; 95% CI 0.79-3.6), but not in Australia (OR = 0.91; 95% CI 0.53-1.6). Seropositivity for betaPV in controls ranged between 52% and 67%. A positive antibody response against 4 or more betaPV types was associated with squamous cell carcinoma in Australia (OR = 2.2; 95% CI 1.4-3.3), the Netherlands (OR = 2.0; 95% CI 1.2-3.4) and fair-skinned Italians (OR = 1.6, 95% CI 0.94- 2.7). The association between UV susceptibility and squamous cell carcinoma was stronger in betaPV-seropositive people. These combined data support the hypothesis that betaPV may play a role in the development of cutaneous squamous cell carcinoma.
| Original language | English |
|---|---|
| Pages (from-to) | 9777-9786 |
| Number of pages | 10 |
| Journal | Cancer Research |
| Volume | 70 |
| Issue number | 23 |
| DOIs | |
| Publication status | Published - Dec 1 2010 |
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ASJC Scopus subject areas
- Cancer Research
- Oncology
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Multicenter study of the association between betapapillomavirus infection and cutaneous squamous cell carcinoma. / Bouwes Bavinck, Jan Nico; Neale, Rachel E.; Abeni, Damiano; Euvrard, Sylvie; Green, Adele C.; Harwood, Catherine A.; De Koning, Maurits N C; Naldi, Luigi; Nindl, Ingo; Pawlita, Michael; Pfister, Herbert; Proby, Charlotte M.; Quint, Wim G V; Ter Schegget, Jan; Waterboer, Tim; Weissenborn, Sönke; Feltkamp, Mariet C W.
In: Cancer Research, Vol. 70, No. 23, 01.12.2010, p. 9777-9786.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Multicenter study of the association between betapapillomavirus infection and cutaneous squamous cell carcinoma
AU - Bouwes Bavinck, Jan Nico
AU - Neale, Rachel E.
AU - Abeni, Damiano
AU - Euvrard, Sylvie
AU - Green, Adele C.
AU - Harwood, Catherine A.
AU - De Koning, Maurits N C
AU - Naldi, Luigi
AU - Nindl, Ingo
AU - Pawlita, Michael
AU - Pfister, Herbert
AU - Proby, Charlotte M.
AU - Quint, Wim G V
AU - Ter Schegget, Jan
AU - Waterboer, Tim
AU - Weissenborn, Sönke
AU - Feltkamp, Mariet C W
PY - 2010/12/1
Y1 - 2010/12/1
N2 - Human papillomaviruses (betaPV) from the beta genus cannot be classified according to their oncogenicity due to a paucity of information. This study evaluates the association between betaPV infection and cutaneous squamous cell carcinoma in conjunction with measures of UV exposure and susceptibility. We performed case-control studies in the Netherlands, Italy, and Australia, countries with profoundly different UV exposures. The presence of 25 betaPV types in eyebrow hair follicles was determined using a highly sensitive HPV DNA genotyping assay, and antibodies for the 15 most prevalent betaPV types in a total of 689 squamous cell carcinoma cases and 845 controls were detected using multiplex serology. Multivariate logistic regression models were used for case-control comparisons and interaction analyses. BetaPV DNA was detected in eyebrow hairs of more than 90% of all participants. The presence of betaPV DNA was associated with an increased risk of squamous cell carcinoma in the Netherlands (OR = 2.8; 95% CI 1.3-5.8) and Italy (OR = 1.7; 95% CI 0.79-3.6), but not in Australia (OR = 0.91; 95% CI 0.53-1.6). Seropositivity for betaPV in controls ranged between 52% and 67%. A positive antibody response against 4 or more betaPV types was associated with squamous cell carcinoma in Australia (OR = 2.2; 95% CI 1.4-3.3), the Netherlands (OR = 2.0; 95% CI 1.2-3.4) and fair-skinned Italians (OR = 1.6, 95% CI 0.94- 2.7). The association between UV susceptibility and squamous cell carcinoma was stronger in betaPV-seropositive people. These combined data support the hypothesis that betaPV may play a role in the development of cutaneous squamous cell carcinoma.
AB - Human papillomaviruses (betaPV) from the beta genus cannot be classified according to their oncogenicity due to a paucity of information. This study evaluates the association between betaPV infection and cutaneous squamous cell carcinoma in conjunction with measures of UV exposure and susceptibility. We performed case-control studies in the Netherlands, Italy, and Australia, countries with profoundly different UV exposures. The presence of 25 betaPV types in eyebrow hair follicles was determined using a highly sensitive HPV DNA genotyping assay, and antibodies for the 15 most prevalent betaPV types in a total of 689 squamous cell carcinoma cases and 845 controls were detected using multiplex serology. Multivariate logistic regression models were used for case-control comparisons and interaction analyses. BetaPV DNA was detected in eyebrow hairs of more than 90% of all participants. The presence of betaPV DNA was associated with an increased risk of squamous cell carcinoma in the Netherlands (OR = 2.8; 95% CI 1.3-5.8) and Italy (OR = 1.7; 95% CI 0.79-3.6), but not in Australia (OR = 0.91; 95% CI 0.53-1.6). Seropositivity for betaPV in controls ranged between 52% and 67%. A positive antibody response against 4 or more betaPV types was associated with squamous cell carcinoma in Australia (OR = 2.2; 95% CI 1.4-3.3), the Netherlands (OR = 2.0; 95% CI 1.2-3.4) and fair-skinned Italians (OR = 1.6, 95% CI 0.94- 2.7). The association between UV susceptibility and squamous cell carcinoma was stronger in betaPV-seropositive people. These combined data support the hypothesis that betaPV may play a role in the development of cutaneous squamous cell carcinoma.
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UR - http://www.scopus.com/inward/citedby.url?scp=78649932185&partnerID=8YFLogxK
U2 - 10.1158/0008-5472.CAN-10-0352
DO - 10.1158/0008-5472.CAN-10-0352
M3 - Article
C2 - 21098702
AN - SCOPUS:78649932185
VL - 70
SP - 9777
EP - 9786
JO - Journal of Cancer Research
JF - Journal of Cancer Research
SN - 0008-5472
IS - 23
ER -