Multicenter study report: Electrophysiological monitoring procedures for subthalamic deep brain stimulation surgery in Parkinson's disease

Sara Marceglia, Simona Mrakic-Sposta, Giorgio Tommasi, Luigi Bartolomei, Camillo Foresti, Franco Valzania, Salvatore Galati, Alessandro Stefani, Filippo Tamma, Alberto Priori

Research output: Contribution to journalArticle

Abstract

Despite the wide diffusion of subthalamic deep brain stimulation (STN-DBS) for Parkinson's disease, systematic practical recommendations for intraoperative electrophysiological monitoring are still lacking. In this paper, a shared protocol for intraoperative electrophysiological monitoring arising from the meetings of a panel of neurophysiologists of the DBS Study Group of the Italian Neurological Society is proposed. Intraoperative monitoring is composed by microrecordings and functional stimulation. In microrecordings, it is recommended to use at least 2-3 electrodes, descending with steps of 0.5-1 mm and waiting at least 60 s before changing the position. Functional stimulation is used to assess the clinical efficacy and the side effects induced by STN-DBS at different positions. Based on the therapeutic window, an algorithm to find the optimal target is proposed. The procedures for intraoperative monitoring for STN-DBS proposed here are safe, relatively cheap, take approximately 30-40 min per side and could offer valuable additional information to the surgeon.

Original languageEnglish
Pages (from-to)449-457
Number of pages9
JournalNeurological Sciences
Volume31
Issue number4
DOIs
Publication statusPublished - Aug 2010

Keywords

  • Deep brain stimulation
  • Electrophysiology
  • Intraoperative monitoring
  • Microrecordings
  • Parkinson's disease

ASJC Scopus subject areas

  • Clinical Neurology
  • Psychiatry and Mental health
  • Dermatology
  • Medicine(all)

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    Marceglia, S., Mrakic-Sposta, S., Tommasi, G., Bartolomei, L., Foresti, C., Valzania, F., Galati, S., Stefani, A., Tamma, F., & Priori, A. (2010). Multicenter study report: Electrophysiological monitoring procedures for subthalamic deep brain stimulation surgery in Parkinson's disease. Neurological Sciences, 31(4), 449-457. https://doi.org/10.1007/s10072-010-0254-0