Abstract
Purpose: Small studies have suggested that older patients have worse outcomes following radical cystectomy (RC) for urothelial carcinoma of the bladder (UCB). We evaluated the association of patient age with clinical outcomes in a large multi-institutional RC series. Methods: Data were collected from 4,429 patients treated with RC and lymphadenectomy for UCB without neoadjuvant chemotherapy. Age at RC was analyzed both as a continuous and categorical variable. Results: Higher age at RC, analyzed as a continuous or categorical variable, was associated with advanced pathologic stage (P <0. 001), higher tumor grade (P = 0. 045), presence of lymphovascular invasion (P = 0. 018), and positive soft-tissue surgical margin status (P = 0. 004). Elderly patients were less likely to receive postoperative chemotherapy (P <0. 001). In multivariable analyses, higher age was associated with disease recurrence, cancer-specific, and overall mortality (P <0. 001). Patients ≥80 years had a significantly greater risk of cancer-specific mortality than patients
| Original language | English |
|---|---|
| Pages (from-to) | 753-759 |
| Number of pages | 7 |
| Journal | World Journal of Urology |
| Volume | 30 |
| Issue number | 6 |
| DOIs | |
| Publication status | Published - Dec 2012 |
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Keywords
- Age
- Prognosis
- Radical cystectomy
- Survival
- Urothelial carcinoma
ASJC Scopus subject areas
- Urology
Cite this
Multicenter validation of the prognostic value of patient age in patients treated with radical cystectomy. / Chromecki, Thomas F.; Mauermann, Julian; Cha, Eugene K.; Svatek, Robert S.; Fajkovic, Harun; Karakiewicz, Pierre I.; Lotan, Yair; Tilki, Derya; Bastian, Patrick J.; Volkmer, Bjoern G.; Montorsi, Francesco; Kassouf, Wassim; Novara, Giacomo; Fritsche, Hans Martin; Ficarra, Vincenzo; Stief, Christian G.; Dinney, Colin P.; Skinner, Eila; Pummer, Karl; Fradet, Yves; Shariat, Shahrokh F.
In: World Journal of Urology, Vol. 30, No. 6, 12.2012, p. 753-759.Research output: Contribution to journal › Article
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TY - JOUR
T1 - Multicenter validation of the prognostic value of patient age in patients treated with radical cystectomy
AU - Chromecki, Thomas F.
AU - Mauermann, Julian
AU - Cha, Eugene K.
AU - Svatek, Robert S.
AU - Fajkovic, Harun
AU - Karakiewicz, Pierre I.
AU - Lotan, Yair
AU - Tilki, Derya
AU - Bastian, Patrick J.
AU - Volkmer, Bjoern G.
AU - Montorsi, Francesco
AU - Kassouf, Wassim
AU - Novara, Giacomo
AU - Fritsche, Hans Martin
AU - Ficarra, Vincenzo
AU - Stief, Christian G.
AU - Dinney, Colin P.
AU - Skinner, Eila
AU - Pummer, Karl
AU - Fradet, Yves
AU - Shariat, Shahrokh F.
PY - 2012/12
Y1 - 2012/12
N2 - Purpose: Small studies have suggested that older patients have worse outcomes following radical cystectomy (RC) for urothelial carcinoma of the bladder (UCB). We evaluated the association of patient age with clinical outcomes in a large multi-institutional RC series. Methods: Data were collected from 4,429 patients treated with RC and lymphadenectomy for UCB without neoadjuvant chemotherapy. Age at RC was analyzed both as a continuous and categorical variable. Results: Higher age at RC, analyzed as a continuous or categorical variable, was associated with advanced pathologic stage (P <0. 001), higher tumor grade (P = 0. 045), presence of lymphovascular invasion (P = 0. 018), and positive soft-tissue surgical margin status (P = 0. 004). Elderly patients were less likely to receive postoperative chemotherapy (P <0. 001). In multivariable analyses, higher age was associated with disease recurrence, cancer-specific, and overall mortality (P <0. 001). Patients ≥80 years had a significantly greater risk of cancer-specific mortality than patients
AB - Purpose: Small studies have suggested that older patients have worse outcomes following radical cystectomy (RC) for urothelial carcinoma of the bladder (UCB). We evaluated the association of patient age with clinical outcomes in a large multi-institutional RC series. Methods: Data were collected from 4,429 patients treated with RC and lymphadenectomy for UCB without neoadjuvant chemotherapy. Age at RC was analyzed both as a continuous and categorical variable. Results: Higher age at RC, analyzed as a continuous or categorical variable, was associated with advanced pathologic stage (P <0. 001), higher tumor grade (P = 0. 045), presence of lymphovascular invasion (P = 0. 018), and positive soft-tissue surgical margin status (P = 0. 004). Elderly patients were less likely to receive postoperative chemotherapy (P <0. 001). In multivariable analyses, higher age was associated with disease recurrence, cancer-specific, and overall mortality (P <0. 001). Patients ≥80 years had a significantly greater risk of cancer-specific mortality than patients
KW - Age
KW - Prognosis
KW - Radical cystectomy
KW - Survival
KW - Urothelial carcinoma
UR - http://www.scopus.com/inward/record.url?scp=84870318871&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84870318871&partnerID=8YFLogxK
U2 - 10.1007/s00345-011-0772-2
DO - 10.1007/s00345-011-0772-2
M3 - Article
VL - 30
SP - 753
EP - 759
JO - World Journal of Urology
JF - World Journal of Urology
SN - 0724-4983
IS - 6
ER -