Multicentre comparative trial of tienilic acid and hydrochlorothiazide in hypertensive patients

C. Ponticelli, A. Lechi, T. di Perri, B. Redaelli, F. Locatelli, E. Rivolta, G. Covi, G. L. Messa, G. Pincella, L. Pedrini, M. Recchia, P. Gouère

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Abstract

To compare the clinical and metabolic effects of a new diuretic uricosuric agent, tienilic acid, with those of hydrochlorothiazide, a multicentre double-blind trial was performed in 56 hypertensive patients. Twenty - eight patients were randomly assigned to take tienilic acid and 28 to take hydrochlorothiazide. The diuretic and anti-hypertensive actions of the two compounds were similar. No significant differences were observed between tienilic acid and hydrochlorothiazide in their effects on urinary and serum electrolytes, hepatic and renal function tests, and fasting lipids. The patients who received tienilic acid showed a significant fall in serum uric acid, mediated by the uricosuric effect. The availability of an agent combining diuretic, anti-hypertensive and hypouricemic effects offers promise in the treatment of arterial hypertension.

Original languageEnglish
Pages (from-to)319-322
Number of pages4
JournalEuropean Journal of Clinical Pharmacology
Volume16
Issue number5
DOIs
Publication statusPublished - Sep 1979

Keywords

  • diuretics
  • hydrochlorothiazide
  • hypertension
  • hyperuricemia
  • hypouricemic drugs
  • tientilic acid

ASJC Scopus subject areas

  • Pharmacology, Toxicology and Pharmaceutics(all)
  • Pharmacology (medical)

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    Ponticelli, C., Lechi, A., di Perri, T., Redaelli, B., Locatelli, F., Rivolta, E., Covi, G., Messa, G. L., Pincella, G., Pedrini, L., Recchia, M., & Gouère, P. (1979). Multicentre comparative trial of tienilic acid and hydrochlorothiazide in hypertensive patients. European Journal of Clinical Pharmacology, 16(5), 319-322. https://doi.org/10.1007/BF00605628