Multicentre evaluation of KONE Optima analysis system

Carlo Ferrero, Annalisa Modenese, Pier Angelo Bonini, Ferruccio Ceriotti, Anna Carobene, Michela Franzin, Walter G. Guder, Walter Hofmann, Matti Puukka, Harri Laitinen, Vladimir Makarovsky, Natalia Gaidukova, Hannu Lampinen

Research output: Contribution to journalArticle

Abstract

Optima from KONE Instruments Corporation is a new selective laboratory analyzer for turbidimetric, colorimetric and ion selective electrode measurements. Overall analytical performance of Optima and reagents provided by KONE was evaluated according to ECCLS guidelines, in a multicentre study involving four different laboratories, including substrates (cholesterol, high-density lipoprotein-cholesterol, creatinine), specific proteins (transferrin, IgG), enzyme activities (γ-glutamyltransferase, alanine aminotransferase) and electrolytes (sodium, potassium, chloride). The results obtained attest good precision of the system for all the analytes tested: the range of within-run CV is 0.5%-4.3%, and range of between-day CV% is 0.8%-7.9% (median of four laboratories). Except for total cholesterol (5% overestimation compared to the reference method) accuracy of measurement is adequate. Creatinine and uric acid assays were subjects of interference (defined as deviation > 10% from target value) by bilirubin and haemoglobin respectively.

Original languageEnglish
Pages (from-to)475-484
Number of pages10
JournalClinical Chemistry and Laboratory Medicine
Volume36
Issue number7
DOIs
Publication statusPublished - 1998

Keywords

  • Chemistry analyzer
  • Ion selective electrodes
  • Laboratory management
  • Precision

ASJC Scopus subject areas

  • Clinical Biochemistry

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  • Cite this

    Ferrero, C., Modenese, A., Bonini, P. A., Ceriotti, F., Carobene, A., Franzin, M., Guder, W. G., Hofmann, W., Puukka, M., Laitinen, H., Makarovsky, V., Gaidukova, N., & Lampinen, H. (1998). Multicentre evaluation of KONE Optima analysis system. Clinical Chemistry and Laboratory Medicine, 36(7), 475-484. https://doi.org/10.1515/CCLM.1998.080