Multicentre Italian family-based association study on tyrosine hydroxylase, catechoi-O-methyl transferase and Wolfram syndrome 1 polymorphisms in mood disorders

Alessandro Serretti, Cristina Cusin, Silvano Cristina, Cristina Lorenzi, Roberta Lilli, Enrico Lattuada, Gaetano Grieco, Alfredo Costa, Filippo Santorelli, Francesco Barale, Enrico Smeraldi, Giuseppe Nappi

Research output: Contribution to journalArticle

Abstract

Objective: The aim of the present study was to investigate tyrosine hydroxylase, catechol-O-methyl transferase and Wolfram syndrome 1 genes in mood disorders using a family-based association approach. Methods: The sample included 134 nuclear mood disorder families, with subjects affected by bipolar disorder (n=103) or major depressive disorder (n=58). All subjects were genotyped using polymerase chain reaction techniques. Results: No significant transmission disequilibrium was found in the overall sample for any polymorphism. Analysis considering bipolar subjects only, or psychopathology traits as affection status did not influence the observed results. Conclusions: The study could not support the involvement of tyrosine hydroxylase, catechol-O-methyl transferase and Wolfram syndrome 1 polymorphisms in mood disorders.

Original languageEnglish
Pages (from-to)121-126
Number of pages6
JournalPsychiatric Genetics
Volume13
Issue number2
DOIs
Publication statusPublished - Jun 2003

Keywords

  • Bipolar disorder
  • Catechol-O-methyl transferase
  • Depressive disorder
  • Tyrosine hydroxylase
  • Wolframine

ASJC Scopus subject areas

  • Genetics(clinical)
  • Psychiatry and Mental health
  • Genetics
  • Neuroscience(all)

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