Multicentre observational study evaluating immediate and progressive switching from carbamazepine to oxcarbazepine in patients with epilepsy

Fiorenzo Albani, Francesca Bisulli, Marta Bartezaghi, Renato Turrini, Agostino Baruzzi

Research output: Contribution to journalArticlepeer-review

Abstract

This observational study was performed to identify the clinical reasons leading physicians to opt for immediate or progressive procedures when switching patients from carbamazepine to oxcarbazepine, end to evaluate the clinical feasibility of the two procedures in a general unselected patient population. Five hundred and twenty-seven patients (aged 14 years or older, treated with carbamazepine as monotherapy or in combination therapy) were recruited at 50 Italian centres and freely assigned to immediate (n=361) or progressive (n=166) switch procedures. Vital and clinical data (including seizure frequency) were comparable in the two groups at baseline. The proportion of patients with simple partial seizures only was significantly higher in the immediate group (immediate: 33.0% vs progressive: 23.5%, p=0.0275), whereas the proportion of patients on combination therapy was slightly higher in the progressive group (immediate: 47.1 vs progressive: 55.4%, p=0.0756). At the end of the switch period, overall treatment satisfaction was greater in the immediate switch group, both in patients (p

Original languageEnglish
Pages (from-to)111-115
Number of pages5
JournalFunctional Neurology
Volume22
Issue number2
Publication statusPublished - Apr 2007

Keywords

  • Carbamazepine
  • Epilepsy
  • Immediate
  • Oxcarbazepine
  • Progressive
  • Switch

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

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